Cocaethylene

Immunologic, hepatic and cardiac effects

Albert D. Arvallo, Ronald R Watson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ethanol and cocaine have opposite pharmacologic effects. Ethanol is a central nervous system depressant. Low amounts of alcoholic beverages increase sociability, while higher levels impair cognitive ability and depress sensorimotor function. The acute in vivo cardiovascular response to moderate levels of ethanol intake involves sympathetic activation, probably due to peripheral vasodilatation, and usually results in an increase in heart rate and maintained or elevated cardiac output [3]. Cardiac arrhythmia seems to be more prevalent. Delbridge et al.‘s recent findings report identifying ethanol at 0.05%(v/v) as a modulator of cardiac contractility. Kinetic analyses indicate that the mechanism of action involves disturbance of sarcoplasmic reticulum function and this may contribute to arrhythmogenic vulnerability - especially in an in vivo context of heightened compensatory sympathetic drive [3]. The study goes on to state that the stabilizing effects of ethanol on intracellular Ca2+ stores may be the cellular basis for the arrhythmogenic response to acute ethanol exposure - a response which is more evident in the normal than in the myopathic myocardium [3].

Original languageEnglish (US)
Title of host publicationAlcohol and Heart Disease
PublisherCRC Press
Pages212-217
Number of pages6
ISBN (Electronic)9780203218853
ISBN (Print)9780415273473
StatePublished - Jan 1 2002

Fingerprint

Ethanol
Liver
Central Nervous System Depressants
Alcoholic Beverages
Sarcoplasmic Reticulum
Cocaine
Vasodilation
Cardiac Output
cocaethylene
Cardiac Arrhythmias
Myocardium
Heart Rate

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Arvallo, A. D., & Watson, R. R. (2002). Cocaethylene: Immunologic, hepatic and cardiac effects. In Alcohol and Heart Disease (pp. 212-217). CRC Press.

Cocaethylene : Immunologic, hepatic and cardiac effects. / Arvallo, Albert D.; Watson, Ronald R.

Alcohol and Heart Disease. CRC Press, 2002. p. 212-217.

Research output: Chapter in Book/Report/Conference proceedingChapter

Arvallo, AD & Watson, RR 2002, Cocaethylene: Immunologic, hepatic and cardiac effects. in Alcohol and Heart Disease. CRC Press, pp. 212-217.
Arvallo AD, Watson RR. Cocaethylene: Immunologic, hepatic and cardiac effects. In Alcohol and Heart Disease. CRC Press. 2002. p. 212-217
Arvallo, Albert D. ; Watson, Ronald R. / Cocaethylene : Immunologic, hepatic and cardiac effects. Alcohol and Heart Disease. CRC Press, 2002. pp. 212-217
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