Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions bromocriptine enhances recovery

Daniel W. Clow, Ronald P Hammer

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

2-[14C]deoxyglucose autoradiography was used to determine local cerebral glucose utilization (ICGU) in rats following chronic cocaine treatment and subsequent abstinence. ICGU was examined in 43 discrete brain regions in animals which had received daily injections of cocaine for 14 days (10 mg/kg) followed by 3 days of saline or bromocriptine (10 mg/kg) treatment. Cocaine abstinence following chronic treatment significantly reduced ICGU in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (NAc). Within the NAc, however, only the rostral pole showed significant reduction. In contrast, when bromocriptine treatment accompanied abstinence, ICGU was no longer reduced in mesocorticolimbic and most other regions, implying that metabolic recovery was enhanced by bromocriptine treatment during early abstinence following chronic cocaine treatment. These data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume4
Issue number1
StatePublished - Jan 1991
Externally publishedYes

Fingerprint

Bromocriptine
Reward
Cocaine
Nucleus Accumbens
Therapeutics
Ventral Tegmental Area
Dopamine Agonists
Deoxyglucose
Brain
Prefrontal Cortex
Autoradiography
Glucose
Injections

Keywords

  • Bromocriptine
  • Cocaine
  • Deoxyglucose
  • Glucose utilization
  • Withdrawal

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions bromocriptine enhances recovery",
abstract = "2-[14C]deoxyglucose autoradiography was used to determine local cerebral glucose utilization (ICGU) in rats following chronic cocaine treatment and subsequent abstinence. ICGU was examined in 43 discrete brain regions in animals which had received daily injections of cocaine for 14 days (10 mg/kg) followed by 3 days of saline or bromocriptine (10 mg/kg) treatment. Cocaine abstinence following chronic treatment significantly reduced ICGU in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (NAc). Within the NAc, however, only the rostral pole showed significant reduction. In contrast, when bromocriptine treatment accompanied abstinence, ICGU was no longer reduced in mesocorticolimbic and most other regions, implying that metabolic recovery was enhanced by bromocriptine treatment during early abstinence following chronic cocaine treatment. These data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine.",
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N2 - 2-[14C]deoxyglucose autoradiography was used to determine local cerebral glucose utilization (ICGU) in rats following chronic cocaine treatment and subsequent abstinence. ICGU was examined in 43 discrete brain regions in animals which had received daily injections of cocaine for 14 days (10 mg/kg) followed by 3 days of saline or bromocriptine (10 mg/kg) treatment. Cocaine abstinence following chronic treatment significantly reduced ICGU in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (NAc). Within the NAc, however, only the rostral pole showed significant reduction. In contrast, when bromocriptine treatment accompanied abstinence, ICGU was no longer reduced in mesocorticolimbic and most other regions, implying that metabolic recovery was enhanced by bromocriptine treatment during early abstinence following chronic cocaine treatment. These data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine.

AB - 2-[14C]deoxyglucose autoradiography was used to determine local cerebral glucose utilization (ICGU) in rats following chronic cocaine treatment and subsequent abstinence. ICGU was examined in 43 discrete brain regions in animals which had received daily injections of cocaine for 14 days (10 mg/kg) followed by 3 days of saline or bromocriptine (10 mg/kg) treatment. Cocaine abstinence following chronic treatment significantly reduced ICGU in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (NAc). Within the NAc, however, only the rostral pole showed significant reduction. In contrast, when bromocriptine treatment accompanied abstinence, ICGU was no longer reduced in mesocorticolimbic and most other regions, implying that metabolic recovery was enhanced by bromocriptine treatment during early abstinence following chronic cocaine treatment. These data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine.

KW - Bromocriptine

KW - Cocaine

KW - Deoxyglucose

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KW - Withdrawal

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