Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery

D. W. Clow, R. P. Hammer

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

2-[14C]deoxyglucose autoradiography was used to determine local cerebral glucose utilization (lCGU) in rats following chronic cocaine treatment and subsequent abstinence. lCGU was examined in 43 discrete brain regions in animals which had received daily injections of cocaine for 14 days (10 mg/kg) followed by 3 days of saline or bromocriptine (10 mg/kg) treatment. Cocaine abstinence following chronic treatment significantly reduced lCGU in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (NAc). Within the NAc, however, only the rostral pole showed significant reduction. In contrast, when bromocriptine treatment accompanied abstinence, lCGU was no longer reduced in mesocorticolimbic and most other regions, implying that metabolic recovery was enhanced by bromocriptine treatment during early abstinence following chronic cocaine treatment. These data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalNeuropsychopharmacology
Volume4
Issue number1
StatePublished - Jan 1 1991
Externally publishedYes

Keywords

  • Bromocriptine
  • Cocaine
  • Deoxyglucose
  • Glucose utilization
  • Withdrawal

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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