Cocaine alters opiate receptor binding in critical brain reward regions

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Brain reward systems are thought to be involved in the reinforcing effect of both cocaine and opiates. In vitro receptor autoradiography was used to determine the effect of chronic, continuous cocaine exposure of 2 weeks duration on [3H]naloxone binding in various regions of rat brain. Although cocaine action in the central nervous system is usually associated with altered dopamine function, we observed that opiate receptor density as labeled by [3H]naloxone was altered by chronic cocaine exposure in critical brain reward regions, including the nucleus accumbens, ventral pallidum, and lateral hypothalamus. Endogenous opioid activity at opiate receptors in these critical regions may be associated with the reinforcement induced by both cocaine and opiates.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalSynapse
Volume3
Issue number1
StatePublished - 1989
Externally publishedYes

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Opioid Receptors
Reward
Cocaine
Opiate Alkaloids
Brain
Naloxone
Lateral Hypothalamic Area
Nucleus Accumbens
Autoradiography
Opioid Analgesics
Dopamine
Central Nervous System

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)
  • Pharmacology

Cite this

Cocaine alters opiate receptor binding in critical brain reward regions. / Hammer, Ronald P.

In: Synapse, Vol. 3, No. 1, 1989, p. 55-60.

Research output: Contribution to journalArticle

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