Cocaine immunotoxicity: abnormal cytokine production in hispanic drug users

Chen Guan-Jie, Radhakrishna Pillai, Julie R. Erickson, Francisca Martinez, Antonio L. Estrada, Ronald Ross Watson

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Peripheral blood lymphocytes from 47 Hispanic poly-drug users with a history of cocaine abuse were analyzed for in vitro production of interleukin-1 (IL-1), interleukin-2 (IL-2), gamma-interferon (IFN) and plasma levels of soluble IL-2 receptor (SIL-2R). Cocaine use was confirmed and quantified by analysis of hair and urine samples, and subjects were grouped into 3 based on the extent of cocaine metabolites detected. No significant differences in IL-1 and IFN production were seen between the 3 groups. However, subjects with higher levels of cocaine in hair also showed higher levels of IL-2. In addition, a positive correlation was seen between cocaine concentrations and IL-2 levels. A corresponding negative correlation was seen between cocaine levels and levels of plasma SIL-2R. These findings suggest modulation of the IL-2 network by cocaine in poly-drug users.

Original languageEnglish (US)
Pages (from-to)81-88
Number of pages8
JournalToxicology letters
Volume59
Issue number1-3
DOIs
StatePublished - Dec 1991

Keywords

  • Cocaine
  • Gamma-interferon
  • Immunodeficiency
  • Interleukin-1
  • Interleukin-2
  • Soluble interleukin-2 receptor

ASJC Scopus subject areas

  • Toxicology

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