Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole

Kent Menkens, Edward J. Bilsky, Kenneth D. Wild, Philip S. Portoghese, Larry D. Reid, Frank Porreca

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Naltrindole, a selective δ-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCl (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pretreated with naltrindole (3 mg/kg i.p.); naltrindole alone showed no reinforcing or aversive effects. The results suggest a novel approach for the treatment of cocaine abuse in man.

Original languageEnglish (US)
Pages (from-to)345-346
Number of pages2
JournalEuropean Journal of Pharmacology
Volume219
Issue number2
DOIs
StatePublished - Aug 25 1992
Externally publishedYes

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naltrindole
Narcotic Antagonists
Cocaine
Cocaine-Related Disorders

Keywords

  • Cocaine
  • Naltrindole
  • Place preference

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole. / Menkens, Kent; Bilsky, Edward J.; Wild, Kenneth D.; Portoghese, Philip S.; Reid, Larry D.; Porreca, Frank.

In: European Journal of Pharmacology, Vol. 219, No. 2, 25.08.1992, p. 345-346.

Research output: Contribution to journalArticle

Menkens, Kent ; Bilsky, Edward J. ; Wild, Kenneth D. ; Portoghese, Philip S. ; Reid, Larry D. ; Porreca, Frank. / Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole. In: European Journal of Pharmacology. 1992 ; Vol. 219, No. 2. pp. 345-346.
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