Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole

Kent Menkens, Edward J. Bilsky, Kenneth D. Wild, Philip S. Portoghese, Larry D. Reid, Frank Porreca

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

Naltrindole, a selective δ-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCl (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pretreated with naltrindole (3 mg/kg i.p.); naltrindole alone showed no reinforcing or aversive effects. The results suggest a novel approach for the treatment of cocaine abuse in man.

Original languageEnglish (US)
Pages (from-to)345-346
Number of pages2
JournalEuropean Journal of Pharmacology
Volume219
Issue number2
DOIs
StatePublished - Aug 25 1992
Externally publishedYes

Keywords

  • Cocaine
  • Naltrindole
  • Place preference

ASJC Scopus subject areas

  • Pharmacology

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