Cocaine self-administration and naltrindole, a delta-selective opioid antagonist

L. D. Reid, S. D. Glick, K. A. Menkens, Edward D French, E. J. Bilsky, Frank Porreca

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Recent reports from several laboratories have suggested a role for delta opioid receptors in expressing some of the biochemical and behavioral effects of cocaine. Here, this possibility has been further explored by evaluating the propensity of rats to self-administer i.v. cocaine in the absence or presence of naltrindole, a selective delta opioid antagonist. Following a number of days of stable cocaine intake, and before a day's session, naltrindole (3 or 10 mg kg-1) reduced pressing for cocaine, regardless of the schedule of reinforcement. These data further support the role of processes associated with delta opioid receptors in the ability of cocaine to reinforce its own use.

Original languageEnglish (US)
Pages (from-to)1409-1412
Number of pages4
JournalNeuroReport
Volume6
Issue number10
StatePublished - 1995

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naltrindole
Self Administration
Narcotic Antagonists
Cocaine
delta Opioid Receptor
Reinforcement Schedule
Aptitude

Keywords

  • Cocaine
  • Delta opioid receptors
  • Naltrindole
  • Opioids
  • Rats
  • Reinforcement
  • Reward
  • Self-administration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Reid, L. D., Glick, S. D., Menkens, K. A., French, E. D., Bilsky, E. J., & Porreca, F. (1995). Cocaine self-administration and naltrindole, a delta-selective opioid antagonist. NeuroReport, 6(10), 1409-1412.

Cocaine self-administration and naltrindole, a delta-selective opioid antagonist. / Reid, L. D.; Glick, S. D.; Menkens, K. A.; French, Edward D; Bilsky, E. J.; Porreca, Frank.

In: NeuroReport, Vol. 6, No. 10, 1995, p. 1409-1412.

Research output: Contribution to journalArticle

Reid, LD, Glick, SD, Menkens, KA, French, ED, Bilsky, EJ & Porreca, F 1995, 'Cocaine self-administration and naltrindole, a delta-selective opioid antagonist', NeuroReport, vol. 6, no. 10, pp. 1409-1412.
Reid, L. D. ; Glick, S. D. ; Menkens, K. A. ; French, Edward D ; Bilsky, E. J. ; Porreca, Frank. / Cocaine self-administration and naltrindole, a delta-selective opioid antagonist. In: NeuroReport. 1995 ; Vol. 6, No. 10. pp. 1409-1412.
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