Coccidioidomycosis as a common cause of community-acquired pneumonia

Lisa Valdivia, David E. Nix, Mark Wright, Elizabeth Lindberg, Timothy Fagan, Donald Lieberman, T'Prien Stoffer, Neil M. Ampel, John N Galgiani

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

The early manifestations of coccidioidomycosis (valley fever) are similar to those of other causes of community-acquired pneumonia (CAP). Without specific etiologic testing, the true frequency of valley fever may be underestimated by public health statistics. Therefore, we conducted a prospective observational study of adults with recent onset of a lower respiratory tract syndrome. Valley fever was serologically confirmed in 16 (29%) of 55 persons (95% confidence interval 16%-44%). Antimicrobial medications were used in 81% of persons with valley fever. Symptomatic differences at the time of enrollment had insufficient predictive value for valley fever to guide clinicians without specific laboratory tests. Thus, valley fever is a common cause of CAP after exposure in a disease-endemic region. If CAP develops in persons who travel or reside in Coccidioides-endemic regions, diagnostic evaluation should routinely include laboratory evaluation for this organism.

Original languageEnglish (US)
Pages (from-to)958-962
Number of pages5
JournalEmerging Infectious Diseases
Volume12
Issue number6
StatePublished - 2006

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Coccidioidomycosis
Pneumonia
Coccidioides
Endemic Diseases
Respiratory System
Observational Studies
Public Health
Prospective Studies
Confidence Intervals

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Valdivia, L., Nix, D. E., Wright, M., Lindberg, E., Fagan, T., Lieberman, D., ... Galgiani, J. N. (2006). Coccidioidomycosis as a common cause of community-acquired pneumonia. Emerging Infectious Diseases, 12(6), 958-962.

Coccidioidomycosis as a common cause of community-acquired pneumonia. / Valdivia, Lisa; Nix, David E.; Wright, Mark; Lindberg, Elizabeth; Fagan, Timothy; Lieberman, Donald; Stoffer, T'Prien; Ampel, Neil M.; Galgiani, John N.

In: Emerging Infectious Diseases, Vol. 12, No. 6, 2006, p. 958-962.

Research output: Contribution to journalArticle

Valdivia, L, Nix, DE, Wright, M, Lindberg, E, Fagan, T, Lieberman, D, Stoffer, TP, Ampel, NM & Galgiani, JN 2006, 'Coccidioidomycosis as a common cause of community-acquired pneumonia', Emerging Infectious Diseases, vol. 12, no. 6, pp. 958-962.
Valdivia L, Nix DE, Wright M, Lindberg E, Fagan T, Lieberman D et al. Coccidioidomycosis as a common cause of community-acquired pneumonia. Emerging Infectious Diseases. 2006;12(6):958-962.
Valdivia, Lisa ; Nix, David E. ; Wright, Mark ; Lindberg, Elizabeth ; Fagan, Timothy ; Lieberman, Donald ; Stoffer, T'Prien ; Ampel, Neil M. ; Galgiani, John N. / Coccidioidomycosis as a common cause of community-acquired pneumonia. In: Emerging Infectious Diseases. 2006 ; Vol. 12, No. 6. pp. 958-962.
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