Coccidioidomycosis in adolescents with lupus nephritis

P. D. Yorgin, M. Rewari, A. Y. Al-Uzri, Andreas A Theodorou, K. M. Scott, L. L. Barton

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Coccidioidomycosis, a fungal infection endemic in the southwestern United States, can cause life-threatening infections in immunosuppressed patients. We report the contrasting cases of two adolescents with lupus nephritis, treated with intravenous pulse cyclophosphamide and daily oral corticosteroids, who developed pulmonary coccidioidomycosis. One patient developed a fatal form of fulminant disseminated coccidioidomycosis, while the other patient developed a solitary pulmonary coccidioides immitis abscess which was responsive to intravenous liposomal amphotericin and fluconazole therapy. Because serologies and initial X-ray studies can be negative, definitive diagnostic studies including bronchioaveolar lavage and needle aspiration should be performed when there is clinical suspicion of coccidioidomycosis in an immunocompromised patient. Immunosuppressed patients with coccidioidomycosis should receive early intravenous amphotericin therapy and may benefit from long-term suppressive antifungal therapy to prevent relapse.

Original languageEnglish (US)
Pages (from-to)77-81
Number of pages5
JournalPediatric Nephrology
Volume16
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Coccidioidomycosis
Lupus Nephritis
Amphotericin B
Southwestern United States
Coccidioides
Lung
Mycoses
Fluconazole
Therapeutic Irrigation
Immunocompromised Host
Serology
Cyclophosphamide
Abscess
Needles
Adrenal Cortex Hormones
Therapeutics
X-Rays
Recurrence
Infection

Keywords

  • Adolescent
  • Amphotericin
  • Coccidioidomycosis
  • Fluconazole
  • Liposomal amphotericin
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Yorgin, P. D., Rewari, M., Al-Uzri, A. Y., Theodorou, A. A., Scott, K. M., & Barton, L. L. (2001). Coccidioidomycosis in adolescents with lupus nephritis. Pediatric Nephrology, 16(1), 77-81. https://doi.org/10.1007/s004670000468

Coccidioidomycosis in adolescents with lupus nephritis. / Yorgin, P. D.; Rewari, M.; Al-Uzri, A. Y.; Theodorou, Andreas A; Scott, K. M.; Barton, L. L.

In: Pediatric Nephrology, Vol. 16, No. 1, 2001, p. 77-81.

Research output: Contribution to journalArticle

Yorgin, PD, Rewari, M, Al-Uzri, AY, Theodorou, AA, Scott, KM & Barton, LL 2001, 'Coccidioidomycosis in adolescents with lupus nephritis', Pediatric Nephrology, vol. 16, no. 1, pp. 77-81. https://doi.org/10.1007/s004670000468
Yorgin, P. D. ; Rewari, M. ; Al-Uzri, A. Y. ; Theodorou, Andreas A ; Scott, K. M. ; Barton, L. L. / Coccidioidomycosis in adolescents with lupus nephritis. In: Pediatric Nephrology. 2001 ; Vol. 16, No. 1. pp. 77-81.
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