Cognitive Behavioral Therapy and Tai Chi Reverse Cellular and Genomic Markers of Inflammation in Late-Life Insomnia: A Randomized Controlled Trial

Michael R. Irwin, Richard Olmstead, Elizabeth C. Breen, Tuff Witarama, Carmen Carrillo, Nina Sadeghi, Jesusa M G Arevalo, Jeffrey Ma, Perry Nicassio, Richard R Bootzin, Steve Cole

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Background Sleep disturbance is associated with activation of systemic and cellular inflammation, as well as proinflammatory transcriptional profiles in circulating leukocytes. Whether treatments that target insomnia-related complaints might reverse these markers of inflammation in older adults with insomnia is not known. Methods In this randomized trial, 123 older adults with insomnia were randomly assigned to cognitive-behavioral therapy for insomnia (CBT-I), tai chi chih (TCC), or sleep seminar education active control condition for 2-hour sessions weekly over 4 months with follow-up at 7 and 16 months. We measured C-reactive protein (CRP) at baseline and months 4 and 16; toll-like receptor-4 activated monocyte production of proinflammatory cytokines at baseline and months 2, 4, 7, and 16; and genome-wide transcriptional profiling at baseline and month 4. Results As compared with sleep seminar education active control condition, CBT-I reduced levels of CRP (months 4 and 16, ps

Original languageEnglish (US)
Pages (from-to)721-729
Number of pages9
JournalBiological Psychiatry
Volume78
Issue number10
DOIs
StatePublished - Nov 15 2015

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Keywords

  • Aging
  • Cognitive-behavioral therapy
  • Gene expression
  • Inflammation
  • Insomnia
  • Tai chi

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Irwin, M. R., Olmstead, R., Breen, E. C., Witarama, T., Carrillo, C., Sadeghi, N., Arevalo, J. M. G., Ma, J., Nicassio, P., Bootzin, R. R., & Cole, S. (2015). Cognitive Behavioral Therapy and Tai Chi Reverse Cellular and Genomic Markers of Inflammation in Late-Life Insomnia: A Randomized Controlled Trial. Biological Psychiatry, 78(10), 721-729. https://doi.org/10.1016/j.biopsych.2015.01.010