Cognitive performance in older women relative to ApoE-ε4 genotype and aerobic fitness

Jennifer L. Etnier, Richard J. Caselli, Eric M. Reiman, Gene E. Alexander, Benjamin A. Sibley, Deron Tessier, Elisabeth C. Mclemore

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

INTRODUCTION: Apolipoprotein E (ApoE) genotype and aerobic fitness are each associated with cognitive performance in older adults. However, their potentially interactive effects on cognitive performance have not been examined. PURPOSE: The primary purpose of this study was to determine whether ApoE genotype and aerobic fitness interact to uniquely impact memory performance and executive functioning. A secondary purpose was to examine the interactive effects on other measures of cognition to provide a more comprehensive assessment of cognitive abilities across a broad range of functions. METHODS: Community-dwelling, cognitively normal older women (N = 90) provided blood samples to allow for assessment of ApoE genotype, completed cognitive tests, and performed a maximal aerobic fitness test. Primary outcome variables were the auditory verbal learning test (AVLT), the complex figures test (CFT), and the Wisconsin card-sorting task (WCST). Secondary outcome variables were the block design test and the paced auditory serial addition task (PASAT). RESULTS: Regression analyses indicated that aerobic fitness was associated with significantly better performance on measures of the AVLT, the CFT, and the PASAT for the ApoE-ε4 homozygotes. CONCLUSION: The preliminary findings from this study support the possibility that aerobic fitness is positively associated with the memory performance of those individuals at most genetic risk for Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalMedicine and Science in Sports and Exercise
Volume39
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Apolipoprotein E4
Apolipoproteins E
Verbal Learning
Genotype
Independent Living
Aptitude
Homozygote
Cognition
Alzheimer Disease
Regression Analysis

Keywords

  • Aging
  • Alzheimer disease
  • Executive function
  • Memory

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine

Cite this

Cognitive performance in older women relative to ApoE-ε4 genotype and aerobic fitness. / Etnier, Jennifer L.; Caselli, Richard J.; Reiman, Eric M.; Alexander, Gene E.; Sibley, Benjamin A.; Tessier, Deron; Mclemore, Elisabeth C.

In: Medicine and Science in Sports and Exercise, Vol. 39, No. 1, 01.2007, p. 199-207.

Research output: Contribution to journalArticle

Etnier, Jennifer L. ; Caselli, Richard J. ; Reiman, Eric M. ; Alexander, Gene E. ; Sibley, Benjamin A. ; Tessier, Deron ; Mclemore, Elisabeth C. / Cognitive performance in older women relative to ApoE-ε4 genotype and aerobic fitness. In: Medicine and Science in Sports and Exercise. 2007 ; Vol. 39, No. 1. pp. 199-207.
@article{de922b9829b04106bfaf77b3a4984741,
title = "Cognitive performance in older women relative to ApoE-ε4 genotype and aerobic fitness",
abstract = "INTRODUCTION: Apolipoprotein E (ApoE) genotype and aerobic fitness are each associated with cognitive performance in older adults. However, their potentially interactive effects on cognitive performance have not been examined. PURPOSE: The primary purpose of this study was to determine whether ApoE genotype and aerobic fitness interact to uniquely impact memory performance and executive functioning. A secondary purpose was to examine the interactive effects on other measures of cognition to provide a more comprehensive assessment of cognitive abilities across a broad range of functions. METHODS: Community-dwelling, cognitively normal older women (N = 90) provided blood samples to allow for assessment of ApoE genotype, completed cognitive tests, and performed a maximal aerobic fitness test. Primary outcome variables were the auditory verbal learning test (AVLT), the complex figures test (CFT), and the Wisconsin card-sorting task (WCST). Secondary outcome variables were the block design test and the paced auditory serial addition task (PASAT). RESULTS: Regression analyses indicated that aerobic fitness was associated with significantly better performance on measures of the AVLT, the CFT, and the PASAT for the ApoE-ε4 homozygotes. CONCLUSION: The preliminary findings from this study support the possibility that aerobic fitness is positively associated with the memory performance of those individuals at most genetic risk for Alzheimer disease.",
keywords = "Aging, Alzheimer disease, Executive function, Memory",
author = "Etnier, {Jennifer L.} and Caselli, {Richard J.} and Reiman, {Eric M.} and Alexander, {Gene E.} and Sibley, {Benjamin A.} and Deron Tessier and Mclemore, {Elisabeth C.}",
year = "2007",
month = "1",
doi = "10.1249/01.mss.0000239399.85955.5e",
language = "English (US)",
volume = "39",
pages = "199--207",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Cognitive performance in older women relative to ApoE-ε4 genotype and aerobic fitness

AU - Etnier, Jennifer L.

AU - Caselli, Richard J.

AU - Reiman, Eric M.

AU - Alexander, Gene E.

AU - Sibley, Benjamin A.

AU - Tessier, Deron

AU - Mclemore, Elisabeth C.

PY - 2007/1

Y1 - 2007/1

N2 - INTRODUCTION: Apolipoprotein E (ApoE) genotype and aerobic fitness are each associated with cognitive performance in older adults. However, their potentially interactive effects on cognitive performance have not been examined. PURPOSE: The primary purpose of this study was to determine whether ApoE genotype and aerobic fitness interact to uniquely impact memory performance and executive functioning. A secondary purpose was to examine the interactive effects on other measures of cognition to provide a more comprehensive assessment of cognitive abilities across a broad range of functions. METHODS: Community-dwelling, cognitively normal older women (N = 90) provided blood samples to allow for assessment of ApoE genotype, completed cognitive tests, and performed a maximal aerobic fitness test. Primary outcome variables were the auditory verbal learning test (AVLT), the complex figures test (CFT), and the Wisconsin card-sorting task (WCST). Secondary outcome variables were the block design test and the paced auditory serial addition task (PASAT). RESULTS: Regression analyses indicated that aerobic fitness was associated with significantly better performance on measures of the AVLT, the CFT, and the PASAT for the ApoE-ε4 homozygotes. CONCLUSION: The preliminary findings from this study support the possibility that aerobic fitness is positively associated with the memory performance of those individuals at most genetic risk for Alzheimer disease.

AB - INTRODUCTION: Apolipoprotein E (ApoE) genotype and aerobic fitness are each associated with cognitive performance in older adults. However, their potentially interactive effects on cognitive performance have not been examined. PURPOSE: The primary purpose of this study was to determine whether ApoE genotype and aerobic fitness interact to uniquely impact memory performance and executive functioning. A secondary purpose was to examine the interactive effects on other measures of cognition to provide a more comprehensive assessment of cognitive abilities across a broad range of functions. METHODS: Community-dwelling, cognitively normal older women (N = 90) provided blood samples to allow for assessment of ApoE genotype, completed cognitive tests, and performed a maximal aerobic fitness test. Primary outcome variables were the auditory verbal learning test (AVLT), the complex figures test (CFT), and the Wisconsin card-sorting task (WCST). Secondary outcome variables were the block design test and the paced auditory serial addition task (PASAT). RESULTS: Regression analyses indicated that aerobic fitness was associated with significantly better performance on measures of the AVLT, the CFT, and the PASAT for the ApoE-ε4 homozygotes. CONCLUSION: The preliminary findings from this study support the possibility that aerobic fitness is positively associated with the memory performance of those individuals at most genetic risk for Alzheimer disease.

KW - Aging

KW - Alzheimer disease

KW - Executive function

KW - Memory

UR - http://www.scopus.com/inward/record.url?scp=33846228270&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846228270&partnerID=8YFLogxK

U2 - 10.1249/01.mss.0000239399.85955.5e

DO - 10.1249/01.mss.0000239399.85955.5e

M3 - Article

C2 - 17218903

AN - SCOPUS:33846228270

VL - 39

SP - 199

EP - 207

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 1

ER -