@article{cf109deeef5349c4866229c12aad1e66,
title = "Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies",
abstract = "The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forthcoming longitudinal studies will build upon a wealth of knowledge gleaned from prior cross-sectional designs to identify early predictors of variability in cognitive function during aging, and characterize fundamental neurobiological mechanisms that underlie the vulnerability to, and the trajectory of, cognitive decline. Finally, we present examples of biological measures that may differentiate mechanisms of the cognitive reserve at the molecular, cellular, and network level.",
keywords = "animal models, biological markers, brain maintenance, cognitive reserve, longitudinal studies",
author = "McQuail, {Joseph A.} and Dunn, {Amy R.} and Yaakov Stern and Barnes, {Carol A.} and Gerd Kempermann and Rapp, {Peter R.} and Kaczorowski, {Catherine C.} and Foster, {Thomas C.}",
note = "Funding Information: This work was supported in part by an Alzheimer{\textquoteright}s Association Research Fellowship AARF-18-565506 (to AD); National Institute on Aging grant AG061263 (to JM); AG063755, AG057914, and AG054180 (to CK); AG061421 (to YS and CB); AG003376 (to CB); AG037984 and AG052258 (to TF); the University of Florida Claude D. Pepper Older American Independence Center (P30-AG028740), the Evelyn F. McKnight Brain Research Foundation, and by the Intramural Research Program of the National Institute on Aging. Funding Information: Funding. This work was supported in part by an Alzheimer?s Association Research Fellowship AARF-18-565506 (to AD); National Institute on Aging grant AG061263 (to JM); AG063755, AG057914, and AG054180 (to CK); AG061421 (to YS and CB); AG003376 (to CB); AG037984 and AG052258 (to TF); the University of Florida Claude D. Pepper Older American Independence Center (P30-AG028740), the Evelyn F. McKnight Brain Research Foundation, and by the Intramural Research Program of the National Institute on Aging. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 McQuail, Dunn, Stern, Barnes, Kempermann, Rapp, Kaczorowski and Foster.",
year = "2021",
month = jan,
day = "21",
doi = "10.3389/fnagi.2020.607685",
language = "English (US)",
volume = "12",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Research Foundation",
}