Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies

Joseph A. McQuail, Amy R. Dunn, Yaakov Stern, Carol A. Barnes, Gerd Kempermann, Peter R. Rapp, Catherine C. Kaczorowski, Thomas C. Foster

Research output: Contribution to journalReview articlepeer-review

Abstract

The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forthcoming longitudinal studies will build upon a wealth of knowledge gleaned from prior cross-sectional designs to identify early predictors of variability in cognitive function during aging, and characterize fundamental neurobiological mechanisms that underlie the vulnerability to, and the trajectory of, cognitive decline. Finally, we present examples of biological measures that may differentiate mechanisms of the cognitive reserve at the molecular, cellular, and network level.

Original languageEnglish (US)
Article number607685
JournalFrontiers in Aging Neuroscience
Volume12
DOIs
StatePublished - Jan 21 2021

Keywords

  • animal models
  • biological markers
  • brain maintenance
  • cognitive reserve
  • longitudinal studies

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

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