Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus

Eunice Molinar, Nivia Rios, Carmenza Spadafora, Anne E Arnold, Phyllis D. Coley, Thomas A. Kursar, William H. Gerwick, Luis Cubilla-Rios

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites 'coibanoles A-C' in reference to Coiba Island and Coiba National Park, Panamá, from which the plant and endophyte were collected. The extract was inactive to the human parasites Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum at a test concentration of 10 μg/mL.

Original languageEnglish (US)
Pages (from-to)919-922
Number of pages4
JournalTetrahedron Letters
Volume53
Issue number8
DOIs
StatePublished - Feb 22 2012

Fingerprint

Pycnoporus
Endophytes
Leishmania donovani
Trypanosoma cruzi
Terpenes
Plasmodium falciparum
Metabolites
Fungi
Islands
Parasites
Recreational Parks

Keywords

  • Coibanoles
  • Leishmania
  • Meroterpenoids
  • Pycnoporus
  • Trypanosoma

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Molinar, E., Rios, N., Spadafora, C., Arnold, A. E., Coley, P. D., Kursar, T. A., ... Cubilla-Rios, L. (2012). Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus. Tetrahedron Letters, 53(8), 919-922. https://doi.org/10.1016/j.tetlet.2011.12.021

Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus. / Molinar, Eunice; Rios, Nivia; Spadafora, Carmenza; Arnold, Anne E; Coley, Phyllis D.; Kursar, Thomas A.; Gerwick, William H.; Cubilla-Rios, Luis.

In: Tetrahedron Letters, Vol. 53, No. 8, 22.02.2012, p. 919-922.

Research output: Contribution to journalArticle

Molinar, E, Rios, N, Spadafora, C, Arnold, AE, Coley, PD, Kursar, TA, Gerwick, WH & Cubilla-Rios, L 2012, 'Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus', Tetrahedron Letters, vol. 53, no. 8, pp. 919-922. https://doi.org/10.1016/j.tetlet.2011.12.021
Molinar, Eunice ; Rios, Nivia ; Spadafora, Carmenza ; Arnold, Anne E ; Coley, Phyllis D. ; Kursar, Thomas A. ; Gerwick, William H. ; Cubilla-Rios, Luis. / Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus. In: Tetrahedron Letters. 2012 ; Vol. 53, No. 8. pp. 919-922.
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