Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus

Eunice Molinar, Nivia Rios, Carmenza Spadafora, A. Elizabeth Arnold, Phyllis D. Coley, Thomas A. Kursar, William H. Gerwick, Luis Cubilla-Rios

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites 'coibanoles A-C' in reference to Coiba Island and Coiba National Park, Panamá, from which the plant and endophyte were collected. The extract was inactive to the human parasites Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum at a test concentration of 10 μg/mL.

Original languageEnglish (US)
Pages (from-to)919-922
Number of pages4
JournalTetrahedron Letters
Volume53
Issue number8
DOIs
StatePublished - Feb 22 2012

Keywords

  • Coibanoles
  • Leishmania
  • Meroterpenoids
  • Pycnoporus
  • Trypanosoma

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Molinar, E., Rios, N., Spadafora, C., Elizabeth Arnold, A., Coley, P. D., Kursar, T. A., Gerwick, W. H., & Cubilla-Rios, L. (2012). Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus. Tetrahedron Letters, 53(8), 919-922. https://doi.org/10.1016/j.tetlet.2011.12.021