Colorectal polyps and their relationship to cancer

E. C. Kim, Michael P Lance

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Autosomal dominant, familial forms of colorectal adenocarcinoma are recognized, but more than 90% of cases are sporadic. Most familial and sporadic cases arise through malignant transformation of benign adenomas in a process known as the adenoma-to-carcinoma sequence. Adenomas are classified histologically as tubular, tubulovillous, or villous. As a neoplasm, adenomas all manifest mild, moderate, or severe dysplasia. The majority (> 90%) of adenomas are small. (< 1 cm in diameter) and do not progress. Risk factors for carcinomatous progression include the presence of multiple adenomas, size greater than or equal to 1 cm, and villous histology or severe dysplasia in adenomas of any size. The adenoma-to-carcinoma sequence advances through the accumulation of lesions involving multiple genes. It appears that similar molecular genetic mechanisms are involved in familial and sporadic forms of colorectal neoplasia.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalGastroenterology Clinics of North America
Volume26
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Polyps
Adenoma
Neoplasms
Carcinoma
Molecular Biology
Histology
Adenocarcinoma
Genes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Colorectal polyps and their relationship to cancer. / Kim, E. C.; Lance, Michael P.

In: Gastroenterology Clinics of North America, Vol. 26, No. 1, 1997, p. 1-17.

Research output: Contribution to journalArticle

@article{8b38b86a5c0f46c885063e0dd7958261,
title = "Colorectal polyps and their relationship to cancer",
abstract = "Autosomal dominant, familial forms of colorectal adenocarcinoma are recognized, but more than 90{\%} of cases are sporadic. Most familial and sporadic cases arise through malignant transformation of benign adenomas in a process known as the adenoma-to-carcinoma sequence. Adenomas are classified histologically as tubular, tubulovillous, or villous. As a neoplasm, adenomas all manifest mild, moderate, or severe dysplasia. The majority (> 90{\%}) of adenomas are small. (< 1 cm in diameter) and do not progress. Risk factors for carcinomatous progression include the presence of multiple adenomas, size greater than or equal to 1 cm, and villous histology or severe dysplasia in adenomas of any size. The adenoma-to-carcinoma sequence advances through the accumulation of lesions involving multiple genes. It appears that similar molecular genetic mechanisms are involved in familial and sporadic forms of colorectal neoplasia.",
author = "Kim, {E. C.} and Lance, {Michael P}",
year = "1997",
doi = "10.1016/S0889-8553(05)70280-6",
language = "English (US)",
volume = "26",
pages = "1--17",
journal = "Gastroenterology Clinics of North America",
issn = "0889-8553",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Colorectal polyps and their relationship to cancer

AU - Kim, E. C.

AU - Lance, Michael P

PY - 1997

Y1 - 1997

N2 - Autosomal dominant, familial forms of colorectal adenocarcinoma are recognized, but more than 90% of cases are sporadic. Most familial and sporadic cases arise through malignant transformation of benign adenomas in a process known as the adenoma-to-carcinoma sequence. Adenomas are classified histologically as tubular, tubulovillous, or villous. As a neoplasm, adenomas all manifest mild, moderate, or severe dysplasia. The majority (> 90%) of adenomas are small. (< 1 cm in diameter) and do not progress. Risk factors for carcinomatous progression include the presence of multiple adenomas, size greater than or equal to 1 cm, and villous histology or severe dysplasia in adenomas of any size. The adenoma-to-carcinoma sequence advances through the accumulation of lesions involving multiple genes. It appears that similar molecular genetic mechanisms are involved in familial and sporadic forms of colorectal neoplasia.

AB - Autosomal dominant, familial forms of colorectal adenocarcinoma are recognized, but more than 90% of cases are sporadic. Most familial and sporadic cases arise through malignant transformation of benign adenomas in a process known as the adenoma-to-carcinoma sequence. Adenomas are classified histologically as tubular, tubulovillous, or villous. As a neoplasm, adenomas all manifest mild, moderate, or severe dysplasia. The majority (> 90%) of adenomas are small. (< 1 cm in diameter) and do not progress. Risk factors for carcinomatous progression include the presence of multiple adenomas, size greater than or equal to 1 cm, and villous histology or severe dysplasia in adenomas of any size. The adenoma-to-carcinoma sequence advances through the accumulation of lesions involving multiple genes. It appears that similar molecular genetic mechanisms are involved in familial and sporadic forms of colorectal neoplasia.

UR - http://www.scopus.com/inward/record.url?scp=0031058602&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031058602&partnerID=8YFLogxK

U2 - 10.1016/S0889-8553(05)70280-6

DO - 10.1016/S0889-8553(05)70280-6

M3 - Article

C2 - 9119435

AN - SCOPUS:0031058602

VL - 26

SP - 1

EP - 17

JO - Gastroenterology Clinics of North America

JF - Gastroenterology Clinics of North America

SN - 0889-8553

IS - 1

ER -