Combination chemotherapy, radiotherapy, and BCG immunotherapy in extensive (metastatic) small cell carcinoma of the lung. A southwest oncology group study

Joseph D. McCcracken, Lance Heilbrun, Joel White, Richard Reed, Michael Samson, Joseph H. Saiers, Ronald Stephens, W. J. Stuckey, John Bickers, Robert Livingston

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

From November 1976 to November 1978, the Southwest Oncology Group treated 254 patients with extensive (metastatic) small cell carcinoma of the lung with combination chemotherapy and radiotherapy with and without BCG immunotherapy. Patients receiving BCG achieved a response rate of 50% versus those patients not receiving BCG of 46% (P = .704). Response duration was 20 weeks for the BCG arms and 23 weeks for the no‐BCG arms; survival was 28 weeks for the BCG arms versus 29 weeks for the no‐BCG arms. An adverse effect in patients surviving more than one year was detected; those continuing to receive BCG had significantly shorter survival, 60 weeks versus 85 weeks (P = .019). Toxicities of the programs were not affected by the addition of BCG immunotherapy. It appears that BCG immunotherapy has no beneficial effect on response rate or duration of response in programs using chemotherapy and radiotherapy for control of metastatic small cell carcinoma of the lung. In addition, because of the adverse effect on long‐term survival, we do not recommend the addition of BCG immunotherapy as a treatment modality in this tumor type.

Original languageEnglish (US)
Pages (from-to)2335-2340
Number of pages6
JournalCancer
Volume46
Issue number11
DOIs
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Combination chemotherapy, radiotherapy, and BCG immunotherapy in extensive (metastatic) small cell carcinoma of the lung. A southwest oncology group study'. Together they form a unique fingerprint.

  • Cite this