Combined chemotherapy plus radiotherapy for treatment of early-stage intermediate- and high-grade non-Hodgkin's lymphoma.

J. H. Briggs, Thomas P Miller

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Treatment of localized (stages I, IE, non-bulky II and IIE) aggressive histologies of non-Hodgkin's lymphoma has evolved over the past 20 years. Prior to 1980, these diseases were shown to be locally controlled with radiotherapy, but systemic relapse and death were common. With the discovery of potentially curative doxorubicin- containing chemotherapy, pilot studies during the 1980s demonstrated the utility of combination chemotherapy as initial therapy by increasing the proportion of cured patients. In the 1990s, two large randomized, prospective trials set the benchmark for future comparisons by establishing initial chemotherapy followed by radiation therapy (combined modality therapy) as the best available current treatment strategy.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalCurrent Oncology Reports
Volume2
Issue number2
StatePublished - Mar 2000

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Non-Hodgkin's Lymphoma
Radiotherapy
Drug Therapy
Benchmarking
Combined Modality Therapy
Combination Drug Therapy
Doxorubicin
Histology
Therapeutics
Recurrence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Combined chemotherapy plus radiotherapy for treatment of early-stage intermediate- and high-grade non-Hodgkin's lymphoma. / Briggs, J. H.; Miller, Thomas P.

In: Current Oncology Reports, Vol. 2, No. 2, 03.2000, p. 176-181.

Research output: Contribution to journalArticle

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