Combining environmental information via hierarchical modeling: An example using mutagenic potencies

Susan J. Simmons, Walter W Piegorsch, Daniela Nitcheva, Errol Zeiger

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mutagenesis assays of toxic environmental agents often provide only a single snapshot of the agent's potential risk, leading to inferences on a possibly isolated phenomenon. Hierarchical models can enhance inferences on environmental agents and obtain more global perspectives on the potential risk. We investigate the use of such models to combine information across environmental studies. We emphasize combination of potency estimates from bioassays used for environmental hazard identification and risk assessment. The models and methods illustrate hierarchical Bayesian techniques to estimate the parameters and make inferences on the unknown potency values.

Original languageEnglish (US)
Pages (from-to)159-168
Number of pages10
JournalEnvironmetrics
Volume14
Issue number2
DOIs
StatePublished - Mar 2003
Externally publishedYes

Fingerprint

Hierarchical Modeling
modeling
global perspective
Mutagenesis
Bioassay
Poisons
environmental hazard
Risk assessment
bioassay
Assays
Identification (control systems)
Hazards
Snapshot
risk assessment
Hierarchical Model
Risk Assessment
assay
Hazard
Estimate
Unknown

Keywords

  • Combining information
  • Hazard identification
  • Hierarchical Bayes methods
  • Hierarchical model
  • Meta-analysis
  • Potency estimation

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Statistics and Probability

Cite this

Combining environmental information via hierarchical modeling : An example using mutagenic potencies. / Simmons, Susan J.; Piegorsch, Walter W; Nitcheva, Daniela; Zeiger, Errol.

In: Environmetrics, Vol. 14, No. 2, 03.2003, p. 159-168.

Research output: Contribution to journalArticle

Simmons, Susan J. ; Piegorsch, Walter W ; Nitcheva, Daniela ; Zeiger, Errol. / Combining environmental information via hierarchical modeling : An example using mutagenic potencies. In: Environmetrics. 2003 ; Vol. 14, No. 2. pp. 159-168.
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