Combining environmental information via hierarchical modeling: An example using mutagenic potencies

Susan J. Simmons, Walter W. Piegorsch, Daniela Nitcheva, Errol Zeiger

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Mutagenesis assays of toxic environmental agents often provide only a single snapshot of the agent's potential risk, leading to inferences on a possibly isolated phenomenon. Hierarchical models can enhance inferences on environmental agents and obtain more global perspectives on the potential risk. We investigate the use of such models to combine information across environmental studies. We emphasize combination of potency estimates from bioassays used for environmental hazard identification and risk assessment. The models and methods illustrate hierarchical Bayesian techniques to estimate the parameters and make inferences on the unknown potency values.

Original languageEnglish (US)
Pages (from-to)159-168
Number of pages10
JournalEnvironmetrics
Volume14
Issue number2
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Keywords

  • Combining information
  • Hazard identification
  • Hierarchical Bayes methods
  • Hierarchical model
  • Meta-analysis
  • Potency estimation

ASJC Scopus subject areas

  • Statistics and Probability
  • Ecological Modeling

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