Common complications of dysregulated inflammation in the neonate

Katherine Newnam, Sheila M Gephart, Lori Wright

Research output: Contribution to journalArticle

Abstract

Preterm infants are faced with a multitude of challenges related to immature systems at delivery placing them at risk for both acute and chronic health conditions. A major component of the human immune system is the inflammatory process and the primary controllers of inflammation are cytokines. Cytokine expression is tightly regulated in the normal host immune response, but in neonates, particularly those born prematurely, the dysregulation is more the norm than the exception. A state in which the inflammatory systems are persistently activated can lead to chronic inflammation affecting the neonate systemically rather than targeting a specific location of illness, injury, or both. Serious neonatal morbidities including white matter injury, chronic lung disease, retinopathy of prematurity and necrotizing enterocolitis have been linked to this chronic inflammatory state. Through the use of a systems approach this article will serve as a focused review of these common neonatal complications. First, an overview explaining the human immune system and the complex process of inflammation will be presented with a focus on systemic neonatal response following acute and/or chronic inflammation. This review is important to promote an understanding of one of the multifactorial influences, inflammation, contributing to long term neonatal health challenges. Empirically supported nursing implications and recommended care strategies are highlighted.

Original languageEnglish (US)
Pages (from-to)154-160
Number of pages7
JournalNewborn and Infant Nursing Reviews
Volume13
Issue number4
DOIs
StatePublished - Dec 2013

Fingerprint

Newborn Infant
Inflammation
Immune System Phenomena
Cytokines
Retinopathy of Prematurity
Necrotizing Enterocolitis
Wounds and Injuries
Systems Analysis
Antigen-Antibody Complex
Premature Infants
Lung Diseases
Immune System
Nursing
Chronic Disease
Morbidity
Health

Keywords

  • Chronic inflammation
  • Chronic lung disease
  • Inflammation
  • Inflammatory disease
  • Necrotizing enterocolitis
  • Neonatal intensive care
  • Prevention
  • Sepsis
  • White matter injury

ASJC Scopus subject areas

  • Pediatrics

Cite this

Common complications of dysregulated inflammation in the neonate. / Newnam, Katherine; Gephart, Sheila M; Wright, Lori.

In: Newborn and Infant Nursing Reviews, Vol. 13, No. 4, 12.2013, p. 154-160.

Research output: Contribution to journalArticle

Newnam, Katherine ; Gephart, Sheila M ; Wright, Lori. / Common complications of dysregulated inflammation in the neonate. In: Newborn and Infant Nursing Reviews. 2013 ; Vol. 13, No. 4. pp. 154-160.
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