Comorbidity analysis according to sex and age in hypertension patients in China

Jiaqi Liu, James Ma, Jiaojiao Wang, Dajun Zeng, Hongbin Song, Ligui Wang, Zhidong Cao

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Hypertension, an important risk factor for the health of human being, is often accompanied by various comorbidities. However, the incidence patterns of those comorbidities have not been widely studied. Aim: Applying big-data techniques on a large collection of electronic medical records, we investigated sex-specific and age-specific detection rates of some important comorbidities of hypertension, and sketched their relationships to reveal the risk for hypertension patients. Methods: We collected a total of 6,371,963 hypertension-related medical records from 106 hospitals in 72 cities throughout China. Those records were reported to a National Center for Disease Control in China between 2011 and 2013. Based on the comprehensive and geographically distributed data set, we identified the top 20 comorbidities of hypertension, and disclosed the sex-specific and age-specific patterns of those comorbidities. A comorbidities network was constructed based on the frequency of co-occurrence relationships among those comorbidities. Results: The top four comorbidities of hypertension were coronary heart disease, diabetes, hyperlipemia, and arteriosclerosis, whose detection rates were 21.71% (21.49% for men vs 21.95% for women), 16.00% (16.24% vs 15.74%), 13.81% (13.86% vs 13.76%), and 12.66% (12.25% vs 13.08%), respectively. The age-specific detection rates of comorbidities showed five unique patterns and also indicated that nephropathy, uremia, and anemia were significant risks for patients under 39 years of age. On the other hand, coronary heart disease, diabetes, arteriosclerosis, hyperlipemia, and cerebral infarction were more likely to occur in older patients. The comorbidity network that we constructed indicated that the top 20 comorbidities of hypertension had strong co-occurrence correlations. Conclusions: Hypertension patients can be aware of their risks of comorbidities based on our sex-specific results, age-specific patterns, and the comorbidity network. Our findings provide useful insights into the comorbidity prevention, risk assessment, and early warning for hypertension patients.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalInternational Journal of Medical Sciences
Volume13
Issue number2
DOIs
StatePublished - Jan 29 2016
Externally publishedYes

Keywords

  • Comorbidity
  • Detection rate
  • Electronic medical records
  • Hypertension
  • Network analysis

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Comorbidity analysis according to sex and age in hypertension patients in China'. Together they form a unique fingerprint.

  • Cite this