Compact CT/SPECT small-animal imaging system

George A. Kastis, Lars R Furenlid, Donald W. Wilson, Todd E. Peterson, H. Bradford Barber, Harrison H Barrett

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The X-ray system comprises a commercially available micro-focus X-ray tube and a CCD-based X-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the X-ray tube/CCD combination. It consists of a 64 × 64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and X-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalIEEE Transactions on Nuclear Science
Volume51
Issue number1 I
DOIs
StatePublished - Feb 2004

Fingerprint

Charge coupled devices
Imaging systems
X ray tubes
animals
Animals
Detectors
X rays
X ray cameras
charge coupled devices
x rays
Set theory
Merging
Gamma rays
Tungsten
Cones
detectors
modules
projection
Cameras
cameras

Keywords

  • Biomedical imaging
  • Cadmium zinc telluride (CdZnTe)
  • Multimodality imaging
  • Single-photon emission computed tomography
  • Small-animal imaging

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering

Cite this

Compact CT/SPECT small-animal imaging system. / Kastis, George A.; Furenlid, Lars R; Wilson, Donald W.; Peterson, Todd E.; Barber, H. Bradford; Barrett, Harrison H.

In: IEEE Transactions on Nuclear Science, Vol. 51, No. 1 I, 02.2004, p. 63-67.

Research output: Contribution to journalArticle

Kastis, George A. ; Furenlid, Lars R ; Wilson, Donald W. ; Peterson, Todd E. ; Barber, H. Bradford ; Barrett, Harrison H. / Compact CT/SPECT small-animal imaging system. In: IEEE Transactions on Nuclear Science. 2004 ; Vol. 51, No. 1 I. pp. 63-67.
@article{f1a87ac0dac8499da1a76b91a0a0211d,
title = "Compact CT/SPECT small-animal imaging system",
abstract = "We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The X-ray system comprises a commercially available micro-focus X-ray tube and a CCD-based X-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the X-ray tube/CCD combination. It consists of a 64 × 64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and X-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed.",
keywords = "Biomedical imaging, Cadmium zinc telluride (CdZnTe), Multimodality imaging, Single-photon emission computed tomography, Small-animal imaging",
author = "Kastis, {George A.} and Furenlid, {Lars R} and Wilson, {Donald W.} and Peterson, {Todd E.} and Barber, {H. Bradford} and Barrett, {Harrison H}",
year = "2004",
month = "2",
doi = "10.1109/TNS.2004.823337",
language = "English (US)",
volume = "51",
pages = "63--67",
journal = "IEEE Transactions on Nuclear Science",
issn = "0018-9499",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "1 I",

}

TY - JOUR

T1 - Compact CT/SPECT small-animal imaging system

AU - Kastis, George A.

AU - Furenlid, Lars R

AU - Wilson, Donald W.

AU - Peterson, Todd E.

AU - Barber, H. Bradford

AU - Barrett, Harrison H

PY - 2004/2

Y1 - 2004/2

N2 - We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The X-ray system comprises a commercially available micro-focus X-ray tube and a CCD-based X-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the X-ray tube/CCD combination. It consists of a 64 × 64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and X-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed.

AB - We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The X-ray system comprises a commercially available micro-focus X-ray tube and a CCD-based X-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the X-ray tube/CCD combination. It consists of a 64 × 64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and X-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed.

KW - Biomedical imaging

KW - Cadmium zinc telluride (CdZnTe)

KW - Multimodality imaging

KW - Single-photon emission computed tomography

KW - Small-animal imaging

UR - http://www.scopus.com/inward/record.url?scp=2342516100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342516100&partnerID=8YFLogxK

U2 - 10.1109/TNS.2004.823337

DO - 10.1109/TNS.2004.823337

M3 - Article

AN - SCOPUS:2342516100

VL - 51

SP - 63

EP - 67

JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

SN - 0018-9499

IS - 1 I

ER -