Comparative effectiveness research: The translational science of comparing the what, how, when, in whom, by whom, and why of treatment effectiveness

Eleanor L. Olvey, Karen MacDonald, Ivo L Abraham

Research output: Contribution to journalArticle

1 Scopus citations


Recent health care legislation in the United States has turned considerable focus to comparative effectiveness research (CER) domestically, though it has been a topic of discussion internationally for many years. Without a fully comprehensive and consistent definition of CER developed, much uncertainty and confusion surrounds its utilization. In addition, contention exists regarding the incorporation of cost and economic considerations as a component of CER. This discussion includes various suggested definitions of CER, methodological considerations, legislation and utilization, and the role of cost-effectiveness evaluations in CER.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalPharmaceuticals Policy and Law
Issue number1
Publication statusPublished - 2012



  • Comparative effectiveness research (CER)
  • effectiveness
  • health technology assessment
  • outcomes
  • pharmacoeconomics

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Health Policy

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