Comparative effects of two gingerol-containing zingiber officinale extracts on experimental Rheumatoid arthritis

Janet L Funk, Jennifer B. Frye, Janice N. Oyarzo, Barbara N. Timmermann

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Ginger (Zingiber officinale) supplements are being promoted for arthritis treatment in western societies on the basis of ginger's traditional use as an anti-inflammatory in Chinese and Ayurvedic medicine. However, scientific evidence of ginger's antiarthritic effects is sparse, and its bioactive joint-protective components have not been identified. Therefore, the ability of a well-characterized crude ginger extract to inhibit joint swelling in an animal model of rheumatoid arthritis, streptococcal cell wall-induced arthritis, was compared to that of a fraction containing only gingerols and their derivatives. Both extracts were efficacious in preventing joint inflammation. However, the crude dichloromethane extract, which also contained essential oils and more polar compounds, was more efficacious (when normalized to gingerol content) in preventing both joint inflammation and destruction. In conclusion, these data document a very significant joint- protective effect of these ginger samples and suggest that nongingerol components are bioactive and can enhance the antiarthritic effects of the more widely studied gingerols.

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalJournal of Natural Products
Volume72
Issue number3
DOIs
StatePublished - Mar 27 2009

Fingerprint

Ginger
Experimental Arthritis
Rheumatoid Arthritis
Joints
Methylene Chloride
Volatile Oils
Complex Mixtures
Medicine
Arthritis
Swelling
Animals
Anti-Inflammatory Agents
Ayurvedic Medicine
Cells
Inflammation
Derivatives
Cell Wall
gingerol
Animal Models

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Comparative effects of two gingerol-containing zingiber officinale extracts on experimental Rheumatoid arthritis. / Funk, Janet L; Frye, Jennifer B.; Oyarzo, Janice N.; Timmermann, Barbara N.

In: Journal of Natural Products, Vol. 72, No. 3, 27.03.2009, p. 403-407.

Research output: Contribution to journalArticle

Funk, Janet L ; Frye, Jennifer B. ; Oyarzo, Janice N. ; Timmermann, Barbara N. / Comparative effects of two gingerol-containing zingiber officinale extracts on experimental Rheumatoid arthritis. In: Journal of Natural Products. 2009 ; Vol. 72, No. 3. pp. 403-407.
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