Comparative efficacy of 10 antimicrobial agents in experimental infections with Bacteroides fragilis

Keith A Joiner, B. Lowe, J. Dzink, J. G. Bartlett

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The comparative efficacy of 10 antimicrobial agents against 15 strains of Bacteroides was examined in vivo using an experimental model of subcutaneous abscesses in mice. Results were evaluated by bacterial counts per lesion with the antimicrobial agents administered beginning 1 hr after challenge. Six drugs reduced counts (mean ± SEM log decrease) significantly compared with values in untreated control animals: metronidazole, 6.7 ± 0.6; clindamycin, 5.0 ± 0.6; moxalactam, 3.8 ± 0.5; cefoxitin, 3.5 ± 0.5; chloramphenicol, 1.6 ± 0.5; and carbenicillin, 1.0 ± 0.3. Antimicrobial agents that had no significant effect compared with values in untreated control animals were cephalothin, cefoperazone, ceforanide, and rosaramicin. Evaluation of several parameters based on in vitro activity and pharmacokinetic properties at the infected site indicated that the time during which the level of antimicrobial agent exceeded the minimal inhibitory concentration correlated best with in vivo antibacterial activity. A delay in the time that treatment was initiated resulted in a marked reduction in in vivo activity.

Original languageEnglish (US)
Pages (from-to)561-568
Number of pages8
JournalJournal of Infectious Diseases
Volume145
Issue number4
StatePublished - 1982
Externally publishedYes

Fingerprint

Bacteroides fragilis
Anti-Infective Agents
Infection
Moxalactam
Carbenicillin
Cefoperazone
Cephalothin
Cefoxitin
Bacteroides
Clindamycin
Bacterial Load
Metronidazole
Chloramphenicol
Abscess
Theoretical Models
Pharmacokinetics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Comparative efficacy of 10 antimicrobial agents in experimental infections with Bacteroides fragilis. / Joiner, Keith A; Lowe, B.; Dzink, J.; Bartlett, J. G.

In: Journal of Infectious Diseases, Vol. 145, No. 4, 1982, p. 561-568.

Research output: Contribution to journalArticle

@article{3d29a691b5bb4a20a4666c1cedcf5ce9,
title = "Comparative efficacy of 10 antimicrobial agents in experimental infections with Bacteroides fragilis",
abstract = "The comparative efficacy of 10 antimicrobial agents against 15 strains of Bacteroides was examined in vivo using an experimental model of subcutaneous abscesses in mice. Results were evaluated by bacterial counts per lesion with the antimicrobial agents administered beginning 1 hr after challenge. Six drugs reduced counts (mean ± SEM log decrease) significantly compared with values in untreated control animals: metronidazole, 6.7 ± 0.6; clindamycin, 5.0 ± 0.6; moxalactam, 3.8 ± 0.5; cefoxitin, 3.5 ± 0.5; chloramphenicol, 1.6 ± 0.5; and carbenicillin, 1.0 ± 0.3. Antimicrobial agents that had no significant effect compared with values in untreated control animals were cephalothin, cefoperazone, ceforanide, and rosaramicin. Evaluation of several parameters based on in vitro activity and pharmacokinetic properties at the infected site indicated that the time during which the level of antimicrobial agent exceeded the minimal inhibitory concentration correlated best with in vivo antibacterial activity. A delay in the time that treatment was initiated resulted in a marked reduction in in vivo activity.",
author = "Joiner, {Keith A} and B. Lowe and J. Dzink and Bartlett, {J. G.}",
year = "1982",
language = "English (US)",
volume = "145",
pages = "561--568",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Comparative efficacy of 10 antimicrobial agents in experimental infections with Bacteroides fragilis

AU - Joiner, Keith A

AU - Lowe, B.

AU - Dzink, J.

AU - Bartlett, J. G.

PY - 1982

Y1 - 1982

N2 - The comparative efficacy of 10 antimicrobial agents against 15 strains of Bacteroides was examined in vivo using an experimental model of subcutaneous abscesses in mice. Results were evaluated by bacterial counts per lesion with the antimicrobial agents administered beginning 1 hr after challenge. Six drugs reduced counts (mean ± SEM log decrease) significantly compared with values in untreated control animals: metronidazole, 6.7 ± 0.6; clindamycin, 5.0 ± 0.6; moxalactam, 3.8 ± 0.5; cefoxitin, 3.5 ± 0.5; chloramphenicol, 1.6 ± 0.5; and carbenicillin, 1.0 ± 0.3. Antimicrobial agents that had no significant effect compared with values in untreated control animals were cephalothin, cefoperazone, ceforanide, and rosaramicin. Evaluation of several parameters based on in vitro activity and pharmacokinetic properties at the infected site indicated that the time during which the level of antimicrobial agent exceeded the minimal inhibitory concentration correlated best with in vivo antibacterial activity. A delay in the time that treatment was initiated resulted in a marked reduction in in vivo activity.

AB - The comparative efficacy of 10 antimicrobial agents against 15 strains of Bacteroides was examined in vivo using an experimental model of subcutaneous abscesses in mice. Results were evaluated by bacterial counts per lesion with the antimicrobial agents administered beginning 1 hr after challenge. Six drugs reduced counts (mean ± SEM log decrease) significantly compared with values in untreated control animals: metronidazole, 6.7 ± 0.6; clindamycin, 5.0 ± 0.6; moxalactam, 3.8 ± 0.5; cefoxitin, 3.5 ± 0.5; chloramphenicol, 1.6 ± 0.5; and carbenicillin, 1.0 ± 0.3. Antimicrobial agents that had no significant effect compared with values in untreated control animals were cephalothin, cefoperazone, ceforanide, and rosaramicin. Evaluation of several parameters based on in vitro activity and pharmacokinetic properties at the infected site indicated that the time during which the level of antimicrobial agent exceeded the minimal inhibitory concentration correlated best with in vivo antibacterial activity. A delay in the time that treatment was initiated resulted in a marked reduction in in vivo activity.

UR - http://www.scopus.com/inward/record.url?scp=0020049279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020049279&partnerID=8YFLogxK

M3 - Article

C2 - 7069236

AN - SCOPUS:0020049279

VL - 145

SP - 561

EP - 568

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -