Comparative Gastrointestinal Blood Loss Associated with Placebo, Aspirin, and Nabumetone as Assessed by Radiochromium (51Cr)

André Lussier, Alan Davis, Yves Lussier, Etienne LeBel

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Nabumetone differs from most other nonsteroidal anti‐inflammatory drugs. It is presented to the gut as a nonacidic prodrug, and is metabolized to its active form after absorption. Studies in animals and humans suggest it is less irritating to the gastrointestinal mucosa. This study compared the gastrointestinal microbleeding induced by nabumetone to aspirin (acetylsalicylic acid, ASA), and placebo in a double blind parallel study using chromium 51Cr labelled red cells to quantitate fecal blood loss (FBL) in healthy volunteers. Thirty subjects were randomized to treatment with nabumetone (2000 mg), ASA (3.6 g) or placebo for 21 days following a 7 day placebo period. Six subjects served as untreated controls. FBL in nabumetone treated subjects was not significantly different to placebo or untreated subjects. In contrast, ASA‐treated subjects exhibited significantly increased FBL than the other 3 groups (P < .0001). 1989 American College of Clinical Pharmacology

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalThe Journal of Clinical Pharmacology
Volume29
Issue number3
DOIs
StatePublished - Mar 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Comparative Gastrointestinal Blood Loss Associated with Placebo, Aspirin, and Nabumetone as Assessed by Radiochromium (<sup>51</sup>Cr)'. Together they form a unique fingerprint.

  • Cite this