Comparative MSH release-inhibiting activities of tocinoic acid (the ring of oxytocin), and L-Pro-L-Leu-Gly-NH2 (the side chain of oxytocin)

Sister Annette Bower, Mac E. Hadley, Victor J Hruby

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Synthetic tocinoic acid, the ring structure of oxytocin (L-Cys-L-Tyr-L-Ile-L-Gln-L-Asn-L-Cys-OH), inhibits MSH release from the rat pituitary in vitro at less than nanogram (10-10 g/ml) levels. A similar inhibitory activity could not be demonstrated on the amphibian (Rana pipiens) pituitary. The synthetic tripeptide side chain of oxytocin (L-Pro-L-Leu-Gly-NH2) was devoid, in vitro, of MSH release inhibition in either the rat or the frog.

Original languageEnglish (US)
Pages (from-to)1185-1191
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume45
Issue number5
DOIs
StatePublished - Dec 3 1971

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MSH Release-Inhibiting Hormone
Melanocyte-Stimulating Hormones
Oxytocin
Rats
Rana pipiens
Amphibians
Anura
In Vitro Techniques
tocinoic acid

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Comparative MSH release-inhibiting activities of tocinoic acid (the ring of oxytocin), and L-Pro-L-Leu-Gly-NH2 (the side chain of oxytocin). / Bower, Sister Annette; Hadley, Mac E.; Hruby, Victor J.

In: Biochemical and Biophysical Research Communications, Vol. 45, No. 5, 03.12.1971, p. 1185-1191.

Research output: Contribution to journalArticle

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