Comparative pharmacokinetics of oral ceftibuten, cefixime, cefaclor, and cefuroxime axetil in healthy volunteers

David E. Nix, William T. Symonds, Judith M. Hyatt, John H. Wilton, Marilyn A. Teal, Pascale Reidenberg, Melton B. Affrime

Research output: Contribution to journalArticle

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Abstract

Study Objective. To compare the pharmacokinetics of ceftibuten, cefixime, cefuroxime axetil, and cefaclor after oral administration. Design. Randomized, four-period, crossover study. Setting. Hospital-based clinical research center. Subjects. Healthy adult men and women volunteers. Interventions. Single 400-mg doses of cefixime and ceftibuten, and 500-mg doses of cefuroxime axetil and cefaclor. Measurements and Main Results. Serum concentrations were determined by high-performance liquid chromatography methods. The mean oral clearances of cefixime, cefuroxime axetil, and cefaclor were similar, ranging from 20.4-27.0 L/hour; clearance of ceftibuten was approximately 4-fold less, 5.45 L/hour. The serum half-lives of ceftibuten (2.35 hrs) and cefixime (2.38 hrs) were prolonged compared with those of cefuroxime axetil (1.30 hrs) and cefaclor (0.693 hr). These agents also differed in terms of time to maximum concentration, time to peak plasma level, area under the curve, and apparent volume of distribution, the last reflecting differences in bioavailability. Conclusion. Ceftibuten had a relatively high time to maximum concentration and long half-life, resulting in a 3.5-fold higher area under the curve than cefixime, cefuroxime axetil, and cefaclor. These pharmacokinetic data can be used as a basis to compare the four oral cephalosporins; however, comparative susceptibility data must also be considered.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalPharmacotherapy
Volume17
Issue number1
StatePublished - Jan 1997

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cefuroxime axetil
Cefixime
Cefaclor
Healthy Volunteers
Pharmacokinetics
Area Under Curve
Cephalosporins
Serum
Cross-Over Studies
Biological Availability
Oral Administration
Half-Life
Volunteers
High Pressure Liquid Chromatography
ceftibuten

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Nix, D. E., Symonds, W. T., Hyatt, J. M., Wilton, J. H., Teal, M. A., Reidenberg, P., & Affrime, M. B. (1997). Comparative pharmacokinetics of oral ceftibuten, cefixime, cefaclor, and cefuroxime axetil in healthy volunteers. Pharmacotherapy, 17(1), 121-125.

Comparative pharmacokinetics of oral ceftibuten, cefixime, cefaclor, and cefuroxime axetil in healthy volunteers. / Nix, David E.; Symonds, William T.; Hyatt, Judith M.; Wilton, John H.; Teal, Marilyn A.; Reidenberg, Pascale; Affrime, Melton B.

In: Pharmacotherapy, Vol. 17, No. 1, 01.1997, p. 121-125.

Research output: Contribution to journalArticle

Nix, DE, Symonds, WT, Hyatt, JM, Wilton, JH, Teal, MA, Reidenberg, P & Affrime, MB 1997, 'Comparative pharmacokinetics of oral ceftibuten, cefixime, cefaclor, and cefuroxime axetil in healthy volunteers', Pharmacotherapy, vol. 17, no. 1, pp. 121-125.
Nix DE, Symonds WT, Hyatt JM, Wilton JH, Teal MA, Reidenberg P et al. Comparative pharmacokinetics of oral ceftibuten, cefixime, cefaclor, and cefuroxime axetil in healthy volunteers. Pharmacotherapy. 1997 Jan;17(1):121-125.
Nix, David E. ; Symonds, William T. ; Hyatt, Judith M. ; Wilton, John H. ; Teal, Marilyn A. ; Reidenberg, Pascale ; Affrime, Melton B. / Comparative pharmacokinetics of oral ceftibuten, cefixime, cefaclor, and cefuroxime axetil in healthy volunteers. In: Pharmacotherapy. 1997 ; Vol. 17, No. 1. pp. 121-125.
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N2 - Study Objective. To compare the pharmacokinetics of ceftibuten, cefixime, cefuroxime axetil, and cefaclor after oral administration. Design. Randomized, four-period, crossover study. Setting. Hospital-based clinical research center. Subjects. Healthy adult men and women volunteers. Interventions. Single 400-mg doses of cefixime and ceftibuten, and 500-mg doses of cefuroxime axetil and cefaclor. Measurements and Main Results. Serum concentrations were determined by high-performance liquid chromatography methods. The mean oral clearances of cefixime, cefuroxime axetil, and cefaclor were similar, ranging from 20.4-27.0 L/hour; clearance of ceftibuten was approximately 4-fold less, 5.45 L/hour. The serum half-lives of ceftibuten (2.35 hrs) and cefixime (2.38 hrs) were prolonged compared with those of cefuroxime axetil (1.30 hrs) and cefaclor (0.693 hr). These agents also differed in terms of time to maximum concentration, time to peak plasma level, area under the curve, and apparent volume of distribution, the last reflecting differences in bioavailability. Conclusion. Ceftibuten had a relatively high time to maximum concentration and long half-life, resulting in a 3.5-fold higher area under the curve than cefixime, cefuroxime axetil, and cefaclor. These pharmacokinetic data can be used as a basis to compare the four oral cephalosporins; however, comparative susceptibility data must also be considered.

AB - Study Objective. To compare the pharmacokinetics of ceftibuten, cefixime, cefuroxime axetil, and cefaclor after oral administration. Design. Randomized, four-period, crossover study. Setting. Hospital-based clinical research center. Subjects. Healthy adult men and women volunteers. Interventions. Single 400-mg doses of cefixime and ceftibuten, and 500-mg doses of cefuroxime axetil and cefaclor. Measurements and Main Results. Serum concentrations were determined by high-performance liquid chromatography methods. The mean oral clearances of cefixime, cefuroxime axetil, and cefaclor were similar, ranging from 20.4-27.0 L/hour; clearance of ceftibuten was approximately 4-fold less, 5.45 L/hour. The serum half-lives of ceftibuten (2.35 hrs) and cefixime (2.38 hrs) were prolonged compared with those of cefuroxime axetil (1.30 hrs) and cefaclor (0.693 hr). These agents also differed in terms of time to maximum concentration, time to peak plasma level, area under the curve, and apparent volume of distribution, the last reflecting differences in bioavailability. Conclusion. Ceftibuten had a relatively high time to maximum concentration and long half-life, resulting in a 3.5-fold higher area under the curve than cefixime, cefuroxime axetil, and cefaclor. These pharmacokinetic data can be used as a basis to compare the four oral cephalosporins; however, comparative susceptibility data must also be considered.

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