Comparing incomparables with the wrong analytics: Anticoagulation, disability, intracranial hemorrhage, and mortality in acute cerebral vein thrombosis

Abdulaziz Saleh Almulhim, Saad Fallatah, Ivo L Abraham

Research output: Contribution to journalLetter

1 Scopus citations

Abstract

Significant progress has been made in the prevention and management of hypercoagulation. Unfractionated heparin (UF) and low molecular weight heparin (LMWH) are indicated for acute cerebral vein thrombosis with or without intracranial hemorrhage (ICH). A recent meta-analysis of four trials comparing UF and LMWH aimed to evaluate the efficacy and safety of both agents in terms of disability, intracranial hemorrhage, and mortality. However, several methodological aspects of the meta-analysis warrant further discussion. It appears that the disability outcome was not sufficiently harmonized by design or statistical standardization, some inputs could not be validated, incorrect statistical analyses were performed, major results could not be replicated, and conclusions were not supported by the statistical results. The conclusion of a statistically significant reduction in mortality is not supported by the data.

Original languageEnglish (US)
Pages (from-to)110-111
Number of pages2
JournalThrombosis Research
Volume178
DOIs
StatePublished - Jun 1 2019

Keywords

  • Anticoagulation
  • Cerebral vein thrombosis
  • Disability
  • Low molecular weight heparin
  • Meta-analysis
  • Mortality

ASJC Scopus subject areas

  • Hematology

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