Comparison of critical drug-drug interaction listings: The department of veterans affairs medical system and standard reference compendia

E. L. Olvey, S. Clauschee, D. C. Malone

Research output: Contribution to journalArticle

47 Scopus citations


The objective of this study was to evaluate the agreement among the US Department of Veterans Affairs (VA) listing of criticaĺ drug-drug interactions (DDIs) and two standard drug-interaction compendia. A list of critical DDIs, as defined by the VA, was compared with two standard commercially available compendia (Micromedex DRUG-REAX and Drug Interactions: Analysis and Management (DIAM)) in order to determine the level of agreement among the systems. Of 982 DDIs classified as critical by the VA, only 136 DDIs (13.7%) were considered critical in all three systems. Our conclusion was that, overall, there is poor agreement among the compendia and the VA system.

Original languageEnglish (US)
Pages (from-to)48-51
Number of pages4
JournalClinical Pharmacology and Therapeutics
Issue number1
StatePublished - Jan 1 2010


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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