Comparison of full-field digital mammography with screen-film mammography for cancer detection: Results of 4,945 paired examinations

J. M. Lewin, R. E. Hendrick, C. J. D'Orsi, P. K. Isaacs, L. J. Moss, A. Karellas, G. A. Sisney, C. C. Kuni, G. R. Cutter

Research output: Contribution to journalArticle

275 Scopus citations

Abstract

PURPOSE: To prospectively compare full-field digital mammography (FFDM) with screen-film mammography (SFM) for cancer detection in a screening population. MATERIALS AND METHODS: At two institutions, 4,945 FFDM examinations were performed in Women aged 40 years and older presenting for SFM. Two views of each breast were acquired with each modality. SFM and FFDM images were interpreted independently. Findings detected With either SFM or FFDM were evaluated with additional imaging and, if warranted, biopsy. RESULTS: Patients in the study underwent 152 biopsies, which resulted in the diagnosis of 35 breast cancers. Twenty-two cancers Were detected with SFM and 21 with FFDM. Four were interval cancers that became palpable within 1 year of screening and were considered false-negative findings with both modalities. The difference in cancer detection rate was not significant. FFDM had a significantly lower recall rate (11.5%; 568 of 4,945) than SFM (1 3.8%; 685 of 4,945) (P < .001, McNemar χ2 model; P < .03, generalized estimating equations model). The positive biopsy rate for findings detected with FFDM (30%; 21 of 69) was higher than that for findings detected with SFM (19%; 22 of 114), but this difference was not significant. CONCLUSION: No difference in cancer detection rate has yet been observed between FFDM and SFM. FFDM has so far led to fewer recalls than SFM.

Original languageEnglish (US)
Pages (from-to)873-880
Number of pages8
JournalRadiology
Volume218
Issue number3
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Breast neoplasms, radiography
  • Breast radiography, comparative studies
  • Breast radiography, technology
  • Cancer screening
  • Radiography, digital

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Lewin, J. M., Hendrick, R. E., D'Orsi, C. J., Isaacs, P. K., Moss, L. J., Karellas, A., Sisney, G. A., Kuni, C. C., & Cutter, G. R. (2001). Comparison of full-field digital mammography with screen-film mammography for cancer detection: Results of 4,945 paired examinations. Radiology, 218(3), 873-880. https://doi.org/10.1148/radiology.218.3.r01mr29873