Comparison of in vivo scintillation probes and gamma cameras for detection of small, deep tumours

H. B. Barber, Harrison H Barrett, J. M. Woolfenden, K. J. Myers, T. S. Hickernell

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

An in vivo probe was compared with a gamma camera for the task of detecting radiolabelled tumour models in a water phantom. The probe, which contained a 1 cm diameter NaI(Tl) detector, was designed and used by the authors for surgical staging studies of gynaecological patients. Tumours were spherical sources of different sizes and activities per unit volume of cobalt-57. The phantom was a tank of water (45 l) containing dissolved radioactivity to simulate background activity. Detector-to-source separations and tank depths were also varied. Camera images of 10 min duration were compared with probe counts of 15 s. For each configuration a large number of source and background runs were analysed using an ideal-observer ROC technique. Area under the ROC curve was used as the figure of merit. Results show that for approximately uniform background the probe should perform substantially better than the gamma camera in detecting small, deep tumours provided that the probe can be manoeuvred to within a few centimetres of the tumour. Mathematical modelling of the results indicates that this conclusion is not dependent on radiopharmaceutical dose, tumour uptake or camera type.

Original languageEnglish (US)
Article number008
Pages (from-to)727-739
Number of pages13
JournalPhysics in Medicine and Biology
Volume34
Issue number6
DOIs
StatePublished - 1989

Fingerprint

Gamma Cameras
Scintillation
scintillation
Tumors
tumors
Cameras
cameras
probes
Neoplasms
Detectors
Source separation
Radiopharmaceuticals
Water
detectors
Radioactivity
maneuvers
Cobalt
radioactivity
ROC Curve
figure of merit

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy (miscellaneous)
  • Biomedical Engineering

Cite this

Comparison of in vivo scintillation probes and gamma cameras for detection of small, deep tumours. / Barber, H. B.; Barrett, Harrison H; Woolfenden, J. M.; Myers, K. J.; Hickernell, T. S.

In: Physics in Medicine and Biology, Vol. 34, No. 6, 008, 1989, p. 727-739.

Research output: Contribution to journalArticle

Barber, H. B. ; Barrett, Harrison H ; Woolfenden, J. M. ; Myers, K. J. ; Hickernell, T. S. / Comparison of in vivo scintillation probes and gamma cameras for detection of small, deep tumours. In: Physics in Medicine and Biology. 1989 ; Vol. 34, No. 6. pp. 727-739.
@article{86f30c3060b74948b0886125b25b7154,
title = "Comparison of in vivo scintillation probes and gamma cameras for detection of small, deep tumours",
abstract = "An in vivo probe was compared with a gamma camera for the task of detecting radiolabelled tumour models in a water phantom. The probe, which contained a 1 cm diameter NaI(Tl) detector, was designed and used by the authors for surgical staging studies of gynaecological patients. Tumours were spherical sources of different sizes and activities per unit volume of cobalt-57. The phantom was a tank of water (45 l) containing dissolved radioactivity to simulate background activity. Detector-to-source separations and tank depths were also varied. Camera images of 10 min duration were compared with probe counts of 15 s. For each configuration a large number of source and background runs were analysed using an ideal-observer ROC technique. Area under the ROC curve was used as the figure of merit. Results show that for approximately uniform background the probe should perform substantially better than the gamma camera in detecting small, deep tumours provided that the probe can be manoeuvred to within a few centimetres of the tumour. Mathematical modelling of the results indicates that this conclusion is not dependent on radiopharmaceutical dose, tumour uptake or camera type.",
author = "Barber, {H. B.} and Barrett, {Harrison H} and Woolfenden, {J. M.} and Myers, {K. J.} and Hickernell, {T. S.}",
year = "1989",
doi = "10.1088/0031-9155/34/6/008",
language = "English (US)",
volume = "34",
pages = "727--739",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "6",

}

TY - JOUR

T1 - Comparison of in vivo scintillation probes and gamma cameras for detection of small, deep tumours

AU - Barber, H. B.

AU - Barrett, Harrison H

AU - Woolfenden, J. M.

AU - Myers, K. J.

AU - Hickernell, T. S.

PY - 1989

Y1 - 1989

N2 - An in vivo probe was compared with a gamma camera for the task of detecting radiolabelled tumour models in a water phantom. The probe, which contained a 1 cm diameter NaI(Tl) detector, was designed and used by the authors for surgical staging studies of gynaecological patients. Tumours were spherical sources of different sizes and activities per unit volume of cobalt-57. The phantom was a tank of water (45 l) containing dissolved radioactivity to simulate background activity. Detector-to-source separations and tank depths were also varied. Camera images of 10 min duration were compared with probe counts of 15 s. For each configuration a large number of source and background runs were analysed using an ideal-observer ROC technique. Area under the ROC curve was used as the figure of merit. Results show that for approximately uniform background the probe should perform substantially better than the gamma camera in detecting small, deep tumours provided that the probe can be manoeuvred to within a few centimetres of the tumour. Mathematical modelling of the results indicates that this conclusion is not dependent on radiopharmaceutical dose, tumour uptake or camera type.

AB - An in vivo probe was compared with a gamma camera for the task of detecting radiolabelled tumour models in a water phantom. The probe, which contained a 1 cm diameter NaI(Tl) detector, was designed and used by the authors for surgical staging studies of gynaecological patients. Tumours were spherical sources of different sizes and activities per unit volume of cobalt-57. The phantom was a tank of water (45 l) containing dissolved radioactivity to simulate background activity. Detector-to-source separations and tank depths were also varied. Camera images of 10 min duration were compared with probe counts of 15 s. For each configuration a large number of source and background runs were analysed using an ideal-observer ROC technique. Area under the ROC curve was used as the figure of merit. Results show that for approximately uniform background the probe should perform substantially better than the gamma camera in detecting small, deep tumours provided that the probe can be manoeuvred to within a few centimetres of the tumour. Mathematical modelling of the results indicates that this conclusion is not dependent on radiopharmaceutical dose, tumour uptake or camera type.

UR - http://www.scopus.com/inward/record.url?scp=0024411151&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024411151&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/34/6/008

DO - 10.1088/0031-9155/34/6/008

M3 - Article

C2 - 2740440

AN - SCOPUS:0024411151

VL - 34

SP - 727

EP - 739

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 6

M1 - 008

ER -