Comparison of procedural complications and in-hospital clinical outcomes between patients with successful and failed percutaneous intervention of coronary chronic total occlusions: A Meta-Analysis of Observational Studies

Muhammad F. Khan, Emmanouil S. Brilakis, Christopher S. Wendel, Hoang Thai

Research output: Contribution to journalArticle

24 Scopus citations


Background Multiple attempts to pass guidewires and balloons across totally occluded segments may result in significant mechanical trauma and higher rates of coronary complications in patients undergoing PCI (percutaneous coronary intervention) for CTOs (chronic total occlusion). It is unknown whether these procedural complications affect short-term survival and in-hospital clinical outcomes after the PCI. The goal of this analysis was to clarify this issue by comparing the rates of adverse in-hospital clinical outcomes between successful and failed CTO-PCI groups. Methods We performed a meta-analysis of 25 studies (16,490 patients) to determine the rates of in-hospital death, myocardial infarction (MI), major adverse cardiovascular events (MACE), and urgent CABG (coronary artery bypass grafting) for the successful and failed CTO-PCI groups. Results Compared to successful CTO PCI, failed CTO PCI procedures were associated with higher in-hospital mortality (1.44% versus 0.5%) [relative risk (RR) of 2.88, 95% confidence interval [CI] (1.96-4.24), P < 0.001], a higher risk of in-hospital MACE (8.88% versus 3.75%) [RR of 2.25, CI (1.69-2.98), P < 0.001], slightly higher risk of in-hospital MI (3.17% versus 2.4%) [RR of 1.35, CI (1.03-1.78), P = 0.03] and increased need for urgent CABG (4.0% versus 0.5%) [RR of 6.67, CI (4.26-10.43), P < 0.001]. Furthermore, higher rates of coronary perforations [RR of 5.0, CI (3.93-6.59), P < 0.001] and cardiac tamponade [RR of 5.0, CI (1.97-12.69), P < 0.001] were observed in the unsuccessful PCI arm. Conclusions As compared to successful interventions, failed PCI attempts for CTOs appear to be associated with higher risk of adverse short-term clinical outcomes.

Original languageEnglish (US)
Pages (from-to)781-794
Number of pages14
JournalCatheterization and Cardiovascular Interventions
Issue number5
StatePublished - Apr 1 2015
Externally publishedYes



  • chronic total occlusions
  • meta-analysis
  • percutaneous coronary intervention
  • peri-procedural complications
  • short-term outcomes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this