Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative

Felix Eckstein, Robert Boudreau, Zhijie Wang, Michael J. Hannon, Jeff Duryea, Wolfgang Wirth, Sebastian Cotofana, Ali Guermazi, Frank Roemer, Michael Nevitt, Markus R. John, Christoph Ladel, Leena Sharma, David J. Hunter, C. Kent Kwoh

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Objective: To evaluate whether change in fixed-location measures of radiographic joint space width (JSW) and cartilage thickness by MRI predict knee replacement. Methods: Knees replaced between 36 and 60 months’ follow-up in the Osteoarthritis Initiative were each matched with one control by age, sex and radiographic status. Radiographic JSW was determined from fixed flexion radiographs and subregional femorotibial cartilage thickness from 3 T MRI. Changes between the annual visit before replacement (T0) and 2 years before T0 (T-2) were compared using conditional logistic regression. Results: One hundred and nineteen knees from 102 participants (55.5 % women; age 64.2 ± 8.7 [mean ± SD] years) were studied. Fixed-location JSW change at 22.5 % from medial to lateral differed more between replaced and control knees (case-control [cc] OR = 1.57; 95 % CI: 1.23–2.01) than minimum medial JSW change (ccOR = 1.38; 95 % CI: 1.11–1.71). Medial femorotibial cartilage loss displayed discrimination similar to minimum JSW, and central tibial cartilage loss similar to fixed-location JSW. Location-independent thinning and thickening scores were elevated prior to knee replacement. Conclusions: Discrimination of structural progression between knee pre-placement cases versus controls was stronger for fixed-location than minimum radiographic JSW. MRI displayed similar discrimination to radiography and suggested greater simultaneous cartilage thickening and loss prior to knee replacement. Key Points: • Fixed-location JSW predicts surgical knee replacement more strongly than minimum JSW. • MRI predicts knee replacement with similar accuracy to radiographic JSW. • MRI reveals greater cartilage thinning and thickening prior to knee replacement.

Original languageEnglish (US)
Pages (from-to)1942-1951
Number of pages10
JournalEuropean Radiology
Volume26
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Clinical validation
  • Knee osteoarthritis
  • Magnetic resonance imaging
  • Measurement performance
  • Radiographic joint space width (JSW)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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