Comparison of the Host Ranges and Antigenicity of Cryptosporidium parvum and Cryptosporidium wrairi from Guinea Pigs

CLARENCE E. CHRISP, MARK A. SUCKOW, RONALD FAYER, MICHAEL J. ARROWOOD, MARK C. HEALEY, CHARLES R. STERLING

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

ABSTRACT. Oocysts of a Cryptosporidium isolate from guinea pigs were not infectious for adult mice, but were infectious for two of three newborn calves and for suckling mice. However, oocysts isolated from calves or mice infected with guinea pig Cryptosporidium were not infectious for guinea pigs. Four isolates of C. parvum from calves were incapable of infecting weanling guinea pigs. Microscopic examination of tissue from the colon and cecum of suckling guinea pigs inoculated with C. parvum revealed sparse infection of some pups. These host range studies and previously described differences in 125I‐labeled oocyst surface protein profiles between Cryptosporidium sp. from guinea pigs and C. parvum suggest they are distinct species. We propose the name Cryptosporidium wrairi be retained. Studies with monoclonal antibodies indicate that C. wrairi and C. parvum are antigenically related.

Original languageEnglish (US)
Pages (from-to)406-409
Number of pages4
JournalThe Journal of Protozoology
Volume39
Issue number3
DOIs
StatePublished - May 1992

Keywords

  • Monoclonal antibodies
  • oocysts
  • sporozoites
  • transmission experiments

ASJC Scopus subject areas

  • Parasitology

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