Comparison of the scanning linear estimator (SLE) and ROI uptake estimation for quantitative 111In-Octreotide SPECT imaging of signals embedded in random backgrounds

Arda Konik, Meridith Kathryn Kupinski, P. Hendrik Pretorius, Michael A. King, Harrison H Barrett

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In quantitative PET and SPECT imaging signal activity is typically estimated from calculations in a 3D region of interest (ROI) of the reconstructed slices. In these calculations, unpredictable bias arising from the null functions of the imaging system (e.g. signal size and location) affects ROI estimates. An alternative to the ROI method is the scanning linear estimator (SLE), which operates on the raw projection data. In this work, we compared the ROI and SLE methods through analytic simulations of a realistic NCAT human phantom modeling 111In-Octreotide studies. The task was to estimate the signal activity of a spherical lesion in the liver, and its size and location are known. The performance of SLE and ROI methods were compared for two assumptions about the activity in the liver: 1) a uniform distribution of known value and 2) a non-uniform and random distribution. For all imaging scenarios in this simulation study the SLE estimated the uptake values better than the ROI estimation when compared using the ensemble-mean-squared error (EMSE).

Original languageEnglish (US)
Title of host publication2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479960972
DOIs
StatePublished - Mar 10 2016
EventIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 - Seattle, United States
Duration: Nov 8 2014Nov 15 2014

Other

OtherIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
CountryUnited States
CitySeattle
Period11/8/1411/15/14

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Konik, A., Kupinski, M. K., Pretorius, P. H., King, M. A., & Barrett, H. H. (2016). Comparison of the scanning linear estimator (SLE) and ROI uptake estimation for quantitative 111In-Octreotide SPECT imaging of signals embedded in random backgrounds. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 [7430907] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2014.7430907