Comparison of the scanning linear estimator (SLE) and ROI uptake estimation for quantitative 111In-Octreotide SPECT imaging of signals embedded in random backgrounds

Arda Konik; Meridith Kathryn Kupinski; P. Hendrik Pretorius; Michael A. King; Harrison H Barrett

doi:10.1109/NSSMIC.2014.7430907

Comparison of the scanning linear estimator (SLE) and ROI uptake estimation for quantitative 111In-Octreotide SPECT imaging of signals embedded in random backgrounds

Arda Konik, Meridith Kathryn Kupinski, P. Hendrik Pretorius, Michael A. King, Harrison H Barrett

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In quantitative PET and SPECT imaging signal activity is typically estimated from calculations in a 3D region of interest (ROI) of the reconstructed slices. In these calculations, unpredictable bias arising from the null functions of the imaging system (e.g. signal size and location) affects ROI estimates. An alternative to the ROI method is the scanning linear estimator (SLE), which operates on the raw projection data. In this work, we compared the ROI and SLE methods through analytic simulations of a realistic NCAT human phantom modeling 111In-Octreotide studies. The task was to estimate the signal activity of a spherical lesion in the liver, and its size and location are known. The performance of SLE and ROI methods were compared for two assumptions about the activity in the liver: 1) a uniform distribution of known value and 2) a non-uniform and random distribution. For all imaging scenarios in this simulation study the SLE estimated the uptake values better than the ROI estimation when compared using the ensemble-mean-squared error (EMSE).

Original language	English (US)
Title of host publication	2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Print)	9781479960972
DOIs	https://doi.org/10.1109/NSSMIC.2014.7430907
State	Published - Mar 10 2016
Event	IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 - Seattle, United States Duration: Nov 8 2014 → Nov 15 2014

Other

Other	IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
Country	United States
City	Seattle
Period	11/8/14 → 11/15/14

ASJC Scopus subject areas

Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

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10.1109/NSSMIC.2014.7430907

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Konik, A., Kupinski, M. K., Pretorius, P. H., King, M. A., & Barrett, H. H. (2016). Comparison of the scanning linear estimator (SLE) and ROI uptake estimation for quantitative 111In-Octreotide SPECT imaging of signals embedded in random backgrounds. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 [7430907] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2014.7430907

Comparison of the scanning linear estimator (SLE) and ROI uptake estimation for quantitative 111In-Octreotide SPECT imaging of signals embedded in random backgrounds. / Konik, Arda; Kupinski, Meridith Kathryn; Pretorius, P. Hendrik; King, Michael A.; Barrett, Harrison H.

2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc., 2016. 7430907.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Konik, A, Kupinski, MK, Pretorius, PH, King, MA & Barrett, HH 2016, Comparison of the scanning linear estimator (SLE) and ROI uptake estimation for quantitative 111In-Octreotide SPECT imaging of signals embedded in random backgrounds. in 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014., 7430907, Institute of Electrical and Electronics Engineers Inc., IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014, Seattle, United States, 11/8/14. https://doi.org/10.1109/NSSMIC.2014.7430907

Konik A, Kupinski MK, Pretorius PH, King MA, Barrett HH. Comparison of the scanning linear estimator (SLE) and ROI uptake estimation for quantitative 111In-Octreotide SPECT imaging of signals embedded in random backgrounds. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc. 2016. 7430907 https://doi.org/10.1109/NSSMIC.2014.7430907

Konik, Arda ; Kupinski, Meridith Kathryn ; Pretorius, P. Hendrik ; King, Michael A. ; Barrett, Harrison H. / Comparison of the scanning linear estimator (SLE) and ROI uptake estimation for quantitative 111In-Octreotide SPECT imaging of signals embedded in random backgrounds. 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc., 2016.

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