Comparisons of the distribution of oesophageal acid exposure throughout the sleep period among the different gastro-oesophageal reflux disease groups

R. Dickman, Sairam Parthasarathy, I. B. Malagon, P. Jones, B. Han, J. Powers, R. Fass

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Abstract

Background: Nocturnal gastro-oesophageal reflux diseases (GERD) can lead to oesophageal mucosal injury and extra-oesophageal complications. Aim: To compare distribution of oesophageal acid exposure during sleep time among patients with non-erosive reflux disease and abnormal pH test (NERD-positive), erosive oesophagitis (EO) and Barrett's oesophagus (BO). Methods: Patients underwent endoscopy followed by 24-h oesophageal pH testing. Oesophageal acid exposure was assessed every 2 h of the sleep period (0-2, 2-4, 4-6 and 6-8 h). Each period of 2 h was evaluated for acid reflux parameters. All groups were matched by age, time from last meal and duration of sleep time. Results: Thirty-eight patients were enrolled (NERD-positive, 16; EO, 1.4; and BO, 8). All GERD groups demonstrated higher oesophageal acid exposure in the first vs. second half of the sleep period as determined by percent time pH <4 (BO: 34.7 vs.11.6, EO: 13.5 vs. 6.9, NERD-positive: 8.8 vs. 2.5, all P < 0.01). In general, patients with BO had a significantly higher distribution of oesophageal acid exposure than those with NERD-positive and EO. Conclusions: Oesophageal acid exposure generally declines throughout the sleep period regardless of GERD group, but BO patients demonstrated the greatest decline during the sleep period.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume26
Issue number1
DOIs
StatePublished - Jul 2007

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Esophageal Diseases
Gastroesophageal Reflux
Barrett Esophagus
Sleep
Esophagitis
Acids
Endoscopy
Meals
Research Design
Wounds and Injuries

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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Comparisons of the distribution of oesophageal acid exposure throughout the sleep period among the different gastro-oesophageal reflux disease groups. / Dickman, R.; Parthasarathy, Sairam; Malagon, I. B.; Jones, P.; Han, B.; Powers, J.; Fass, R.

In: Alimentary Pharmacology and Therapeutics, Vol. 26, No. 1, 07.2007, p. 41-48.

Research output: Contribution to journalArticle

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