Compartmentation of glycolytic and glycogenolytic metabolism in vascular smooth muscle

Ron Lynch, Richard J. Paul

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Vascular smooth muscle is characterized by a high rate of aerobic lactate production, which may be altered independently of oxidative phosphorylation. This finding suggested a cytoplasmic compartmentation of metabolism. Exogenous glucose was found to be the sole precursor of aerobic glycolysis under unstimulated conditions. Although tissue depolarization with high K+ resulted in a substantial reduction of endogenous glycogen, exogenous glucose remained the sole precursor of aerobic lactate production. These data showed unequivocally that carbohydrate metabolism is compartmentalized in vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)1344-1346
Number of pages3
JournalScience
Volume222
Issue number4630
StatePublished - 1983
Externally publishedYes

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Vascular Smooth Muscle
Lactic Acid
Glucose
Oxidative Phosphorylation
Carbohydrate Metabolism
Glycolysis
Glycogen

ASJC Scopus subject areas

  • General

Cite this

Compartmentation of glycolytic and glycogenolytic metabolism in vascular smooth muscle. / Lynch, Ron; Paul, Richard J.

In: Science, Vol. 222, No. 4630, 1983, p. 1344-1346.

Research output: Contribution to journalArticle

Lynch, Ron ; Paul, Richard J. / Compartmentation of glycolytic and glycogenolytic metabolism in vascular smooth muscle. In: Science. 1983 ; Vol. 222, No. 4630. pp. 1344-1346.
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