Compartmentation of glycolytic and glycogenolytic metabolism in vascular smooth muscle

Ronald M. Lynch, Richard J. Paul

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Vascular smooth muscle is characterized by a high rate of aerobic lactate production, which may be altered independently of oxidative phosphorylation. This finding suggested a cytoplasmic compartmentation of metabolism. Exogenous glucose was found to be the sole precursor of aerobic glycolysis under unstimulated conditions. Although tissue depolarization with high K+ resulted in a substantial reduction of endogenous glycogen, exogenous glucose remained the sole precursor of aerobic lactate production. These data showed unequivocally that carbohydrate metabolism is compartmentalized in vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)1344-1346
Number of pages3
JournalScience
Volume222
Issue number4630
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • General

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