Complementary Detection of Multiple Electrical Sources in Tissue Using Acoustoelectric Effects

Zhaohui Wang, Rajab Challoo, Hu Peng, Chung S. Leung, Russell S Witte

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Accurate 3-D mapping of multiple bioelectric sources in nerve fibers with high spatial resolution is challenging for the diagnosis and treatment of a variety of neural abnormalities. Ultrasound current source density imaging exploits the acoustoelectric (AE) effect, an interaction between electrical current and acoustic pressure waves propagating through a conducting material, and has distinct advantages over conventional electrophysiology (i.e., without ultrasound) for mapping electrical current flow in tissue. Ultrasound current source density imaging and two complementary Wheatstone bridge circuits were used to simultaneously detect two separate current flows induced in tissue phantoms. It has been found that the addition and subtraction of AE signals acquired by two circuits are independent components, regardless of whether the two sources are positioned at the same or different depths. In the ultrasound field, the AE signal from the bridge circuits is stronger, with a higher signal-to-noise ratio, than without a bridge circuit. Both experimental and simulated AE images depend on the magnitude and direction of the current, as well as the geometry (shape and thickness) and location of the current sources in the ultrasound field (2.25-MHz transducer). The experimental results are consistent with simulations consisting of multiple current sources. Real-time 3-D ultrasound current source density images of multiple current flows co-registered with convention pulse echo ultrasound potentially facilitate monitoring of neurologic disorders.

Original languageEnglish (US)
Pages (from-to)2323-2333
Number of pages11
JournalUltrasound in Medicine and Biology
Volume42
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Electrophysiology
Signal-To-Noise Ratio
Nervous System Diseases
Transducers
Nerve Fibers
Pressure
electrophysiology
Wheatstone bridges
nerve fibers
abnormalities
elastic waves
subtraction
echoes
transducers
signal to noise ratios
spatial resolution
Direction compound
disorders
conduction
acoustics

Keywords

  • Acoustoelectric
  • Bioelectric
  • Electroencephalography
  • Electrophysiology
  • Mapping

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Complementary Detection of Multiple Electrical Sources in Tissue Using Acoustoelectric Effects. / Wang, Zhaohui; Challoo, Rajab; Peng, Hu; Leung, Chung S.; Witte, Russell S.

In: Ultrasound in Medicine and Biology, Vol. 42, No. 9, 01.09.2016, p. 2323-2333.

Research output: Contribution to journalArticle

Wang, Zhaohui ; Challoo, Rajab ; Peng, Hu ; Leung, Chung S. ; Witte, Russell S. / Complementary Detection of Multiple Electrical Sources in Tissue Using Acoustoelectric Effects. In: Ultrasound in Medicine and Biology. 2016 ; Vol. 42, No. 9. pp. 2323-2333.
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