Complex evolutionary history of felid anelloviruses

Simona Kraberger, Laurel EK Serieys, Cécile Richet, Nicholas M. Fountain-Jones, Guy Baele, Jacqueline M. Bishop, Mary Nehring, Jacob S. Ivan, Eric S. Newkirk, John R. Squires, Michael C. Lund, Seth PD Riley, Christopher C. Wilmers, Paul D. van Helden, Koenraad Van Doorslaer, Melanie Culver, Sue VandeWoude, Darren P. Martin, Arvind Varsani

Research output: Contribution to journalArticlepeer-review

Abstract

Anellovirus infections are highly prevalent in mammals, however, prior to this study only a handful of anellovirus genomes had been identified in members of the Felidae family. Here we characterise anelloviruses in pumas (Puma concolor), bobcats (Lynx rufus), Canada lynx (Lynx canadensis), caracals (Caracal caracal) and domestic cats (Felis catus). The complete anellovirus genomes (n = 220) recovered from 149 individuals were diverse. ORF1 protein sequence similarity network analysis coupled with phylogenetic analysis, revealed two distinct clusters that are populated by felid-derived anellovirus sequences, a pattern mirroring that observed for the porcine anelloviruses. Of the two-felid dominant anellovirus groups, one includes sequences from bobcats, pumas, domestic cats and an ocelot, and the other includes sequences from caracals, Canada lynx, domestic cats and pumas. Coinfections of diverse anelloviruses appear to be common among the felids. Evidence of recombination, both within and between felid-specific anellovirus groups, supports a long coevolution history between host and virus.

Original languageEnglish (US)
Pages (from-to)176-189
Number of pages14
JournalVirology
Volume562
DOIs
StatePublished - Oct 2021

Keywords

  • Anelloviridae
  • Bobcat
  • Canada lynx
  • Caracal
  • Domestic cat
  • Puma
  • Torque teno virus

ASJC Scopus subject areas

  • Virology

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