Complex pedigrees in the sequencing era: To track transmissions or decorrelate?

Dalin Li, Jin Zhou, Duncan C. Thomas, David W. Fardo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Next-generation sequencing (NGS) studies are becoming commonplace, and the NGS field is continuing to develop rapidly. Analytic methods aimed at testing for the various roles that genetic susceptibility plays in disease are also rapidly being developed and optimized. Studies that incorporate large, complex pedigrees are of particular importance because they provide detailed information about inheritance patterns and can be analyzed in a variety of complementary ways. The nine contributions from our Genetic Analysis Workshop 18 working group on family-based tests of association for rare variants using simulated data examined analytic methods for testing genetic association using whole-genome sequencing data from 20 large pedigrees with 200 phenotype simulation replicates. What distinguishes the approaches explored is how the complexities of analyzing familial genetic data were handled. Here, we explore the methods that either harness inheritance patterns and transmission information or attempt to adjust for the correlation between family members in order to utilize computationally and conceptually simpler statistical testing procedures. Although directly comparing these two classes of approaches across contributions is difficult, we note that the two classes balance robustness to population stratification and computational complexity (the transmission-based approaches) with simplicity and increased power, assuming no population stratification or proper adjustment for it (decorrelation approaches).

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume38
Issue numberSUPPL.1
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Pedigree
Inheritance Patterns
Genetic Testing
Genetic Predisposition to Disease
Population
Genome
Phenotype
Education

Keywords

  • Decorrelation strategies
  • Family-based association testing
  • Genetic analysis workshop 18
  • Next-generation sequencing

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Complex pedigrees in the sequencing era : To track transmissions or decorrelate? / Li, Dalin; Zhou, Jin; Thomas, Duncan C.; Fardo, David W.

In: Genetic Epidemiology, Vol. 38, No. SUPPL.1, 2014.

Research output: Contribution to journalArticle

Li, Dalin ; Zhou, Jin ; Thomas, Duncan C. ; Fardo, David W. / Complex pedigrees in the sequencing era : To track transmissions or decorrelate?. In: Genetic Epidemiology. 2014 ; Vol. 38, No. SUPPL.1.
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