Components of metabolic syndrome and metachronous colorectal neoplasia

Erin L. Ashbeck, Elizabeth T Jacobs, María Elena Martínez, Eugene W. Gerner, Michael P Lance, Patricia A. Thompson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: The consistent association between obesity and colorectal cancer is thought to be explained by metabolic disturbances common, but not exclusive, to the obese. Methods: We assessed the relation between metachronous neoplasia and the components of metabolic syndrome (MetS) as defined by the National Cholesterol Education Program's Adult Treatment Panel III in 2,392 participants of two previously conducted chemoprevention trials. Waist circumference, fasting plasma glucose, trigylcerides, high-density lipoprotein, and systolic and diastolic blood pressure were measured at baseline. Results: MetS classification was associated with increased odds of metachronous neoplasia among women [odds ratio (OR), 1.37; 95% confidence interval (95% CI), 1.01-1.85] but not among men (OR, 0.99; 95% CI, 0.81-1.21). High waist circumference in men (OR, 1.41; 95% CI, 1.15-1.72) and women (OR, 1.41; 95% CI, 1.05-1.90) and elevated fasting glucose in women (OR, 1.46; 95% CI, 1.09-1.96), as defined by Adult Treatment Panel III cutpoints, were associated with increased odds, whereas none of the other criteria were independently associated with metachronous neoplasia. When each trait was evaluated using quartiles, elevated glucose among women and large waist circumference among men were significantly associated with metachronous lesions. Exploratory analysis of waist circumference and fasting glucose suggested an interaction, where only the combination of large waist circumference and elevated glucose conferred significant increased odds of metachronous neoplasia among both men (OR, 1.36; 95% CI, 1.04-1.78; Pinteraction = 0.08) and women (OR, 1.83; 95% CI, 1.26-2.67; Pinteraction = 0.12). Conclusions: These results suggest that, of the specific components of MetS, those that capture impaired glucose uptake increased the odds of metachronous neoplasia.

Original languageEnglish (US)
Pages (from-to)1134-1143
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume18
Issue number4
DOIs
StatePublished - Apr 2009

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Waist Circumference
Odds Ratio
Confidence Intervals
Glucose
Neoplasms
Fasting
Blood Pressure
Chemoprevention
HDL Lipoproteins
Colorectal Neoplasms
Obesity
Cholesterol
Education
Therapeutics

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Components of metabolic syndrome and metachronous colorectal neoplasia. / Ashbeck, Erin L.; Jacobs, Elizabeth T; Martínez, María Elena; Gerner, Eugene W.; Lance, Michael P; Thompson, Patricia A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 18, No. 4, 04.2009, p. 1134-1143.

Research output: Contribution to journalArticle

Ashbeck, Erin L. ; Jacobs, Elizabeth T ; Martínez, María Elena ; Gerner, Eugene W. ; Lance, Michael P ; Thompson, Patricia A. / Components of metabolic syndrome and metachronous colorectal neoplasia. In: Cancer Epidemiology Biomarkers and Prevention. 2009 ; Vol. 18, No. 4. pp. 1134-1143.
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AU - Thompson, Patricia A.

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