Computational approaches to phenotyping: High-throughput phenomics

Yves A. Lussier, Yang Liu

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

The recent completion of the Human Genome Project has made possible a high-throughput "systems approach" for accelerating the elucidation of molecular underpinnings of human diseases, and subsequent derivation of molecular-based strategies to more effectively prevent, diagnose, and treat these diseases. Although altered phenotypes are among the most reliable manifestations of altered gene functions, research using systematic analysis of phenotype relationships to study human biology is still in its infancy. This article focuses on the emerging field of high-throughput phenotyping (HTP) phenomics research, which aims to capitalize on novel high-throughput computation and informatics technology developments to derive genomewide molecular networks of genotype-phenotype associations,or "phenomic associations." The HTP phenomics research field faces the challenge of technological research and development to generate novel tools in computation and informatics that will allow researchers to amass, access, integrate, organize, and manage phenotypic databases across species and enable genomewide analysis to associate phenotypic information with genomic data at different scales of biology. Key state-of-the-art technological advancements critical for HTP phenomics research are covered in this review. In particular, we highlight the power of computational approaches to conduct large-scale phenomics studies.

Original languageEnglish (US)
Pages (from-to)18-25
Number of pages8
JournalProceedings of the American Thoracic Society
Volume4
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Computational genomics
  • Gene-disease associations
  • Phenomics
  • Phenotype

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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