Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus

Jean-Marc Fellous, P. H E Tiesinga, J. V. José, T. J. Sejnowski

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Application of carbachol (cch) can induce oscillations in the δ (cch-δ, 0.5-2 Hz), θ (cch-θ, 4-12 Hz), and γ (cch-γ, 30-80 Hz) frequency-range in the rat hippocampal slice preparation. Using model CA3 cells we found that the time scale for cch-δ was determined by the decay constant of IK-AHP, that of cch-θ by an intrinsic subthreshold membrane potential oscillation, and that of cch-γ by the decay constant of GABA-ergic postsynaptic potentials. The known physiological effects of carbachol on IM, and IK-AHP, and on the strength of excitatory postsynaptic potentials produced the observed transitions from incoherent cch-θ to cch-δ, and from cch-δ to cch-θ with increasing cch concentrations, as well as the nested cch-γ-δ and cch-γ-θ seen in experiment.

Original languageEnglish (US)
Pages (from-to)587-593
Number of pages7
JournalNeurocomputing
Volume38-40
DOIs
StatePublished - Jun 2001
Externally publishedYes

Fingerprint

Carbachol
Rats
Hippocampus
Membranes
Experiments
Synaptic Potentials
Excitatory Postsynaptic Potentials
Membrane Potentials
gamma-Aminobutyric Acid

Keywords

  • Biophysical model
  • Neuromodulator
  • Oscillation
  • Synchrony

ASJC Scopus subject areas

  • Artificial Intelligence
  • Cellular and Molecular Neuroscience

Cite this

Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus. / Fellous, Jean-Marc; Tiesinga, P. H E; José, J. V.; Sejnowski, T. J.

In: Neurocomputing, Vol. 38-40, 06.2001, p. 587-593.

Research output: Contribution to journalArticle

Fellous, Jean-Marc ; Tiesinga, P. H E ; José, J. V. ; Sejnowski, T. J. / Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus. In: Neurocomputing. 2001 ; Vol. 38-40. pp. 587-593.
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