Computed tomography of gastrointestinal inflammation after bone marrow transplantation

B. Jones, E. K. Fishman, S. S. Kramer, S. S. Siegelman, R. Saral, W. E. Beschorner, A. M. Yeager, A. M. Lake, R. H. Yolken, P. Tutschka

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43 Scopus citations

Abstract

Overwhelming secretory diarrhea can be a major complication after bone marrow transplantation, associated usually with acute graft-versus-host disease (AGVHD). Radiographic evaluation may be hampered by nausea, vomiting, or debilitation. Computed tomography (CT) in seven such patients demonstrated diffuse wall thickening in the small intestine, colon, and/or mesentery. In two cases, prolonged adherence of oral contrast material to the luminal surface resulted in bizarre patterns of coating. In two others, a layer of low attenuation within the thickened wall produced a target appearance consistent with submucosal edema or hemorrhage. Small bowel dilatation and fold enlargement was the only finding in one patient. The role that superinfection of the gastrointestinal tract with opportunistic organisms can play in this immunocompromised group of patients is less well established. In this group of patients, the findings were due to AGVHD in two, AGVHD and viral enteritis in two, and viral enteritis alone in three. CT may be an alternative to routine contrast studies in assessing the extent of gastrointestinal tract involvement after bone marrow transplantation. Neither contrast studies nor CT were able to differentiate between AGVHD and viral enteritis.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalAmerican Journal of Roentgenology
Volume146
Issue number4
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Jones, B., Fishman, E. K., Kramer, S. S., Siegelman, S. S., Saral, R., Beschorner, W. E., Yeager, A. M., Lake, A. M., Yolken, R. H., & Tutschka, P. (1986). Computed tomography of gastrointestinal inflammation after bone marrow transplantation. American Journal of Roentgenology, 146(4), 691-695. https://doi.org/10.2214/ajr.146.4.691