Computed tomography of gastrointestinal inflammation after bone marrow transplantation

B. Jones, E. K. Fishman, S. S. Kramer, S. S. Siegelman, R. Saral, W. E. Beschorner, Andrew M Yeager, A. M. Lake, R. H. Yolken, P. Tutschka

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Overwhelming secretory diarrhea can be a major complication after bone marrow transplantation, associated usually with acute graft-versus-host disease (AGVHD). Radiographic evaluation may be hampered by nausea, vomiting, or debilitation. Computed tomography (CT) in seven such patients demonstrated diffuse wall thickening in the small intestine, colon, and/or mesentery. In two cases, prolonged adherence of oral contrast material to the luminal surface resulted in bizarre patterns of coating. In two others, a layer of low attenuation within the thickened wall produced a target appearance consistent with submucosal edema or hemorrhage. Small bowel dilatation and fold enlargement was the only finding in one patient. The role that superinfection of the gastrointestinal tract with opportunistic organisms can play in this immunocompromised group of patients is less well established. In this group of patients, the findings were due to AGVHD in two, AGVHD and viral enteritis in two, and viral enteritis alone in three. CT may be an alternative to routine contrast studies in assessing the extent of gastrointestinal tract involvement after bone marrow transplantation. Neither contrast studies nor CT were able to differentiate between AGVHD and viral enteritis.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalAmerican Journal of Roentgenology
Volume146
Issue number4
StatePublished - 1986
Externally publishedYes

Fingerprint

Graft vs Host Disease
Bone Marrow Transplantation
Enteritis
Tomography
Inflammation
Gastrointestinal Tract
Superinfection
Mesentery
Immunocompromised Host
Nausea
Contrast Media
Small Intestine
Vomiting
Dilatation
Diarrhea
Edema
Colon
Hemorrhage

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Jones, B., Fishman, E. K., Kramer, S. S., Siegelman, S. S., Saral, R., Beschorner, W. E., ... Tutschka, P. (1986). Computed tomography of gastrointestinal inflammation after bone marrow transplantation. American Journal of Roentgenology, 146(4), 691-695.

Computed tomography of gastrointestinal inflammation after bone marrow transplantation. / Jones, B.; Fishman, E. K.; Kramer, S. S.; Siegelman, S. S.; Saral, R.; Beschorner, W. E.; Yeager, Andrew M; Lake, A. M.; Yolken, R. H.; Tutschka, P.

In: American Journal of Roentgenology, Vol. 146, No. 4, 1986, p. 691-695.

Research output: Contribution to journalArticle

Jones, B, Fishman, EK, Kramer, SS, Siegelman, SS, Saral, R, Beschorner, WE, Yeager, AM, Lake, AM, Yolken, RH & Tutschka, P 1986, 'Computed tomography of gastrointestinal inflammation after bone marrow transplantation', American Journal of Roentgenology, vol. 146, no. 4, pp. 691-695.
Jones B, Fishman EK, Kramer SS, Siegelman SS, Saral R, Beschorner WE et al. Computed tomography of gastrointestinal inflammation after bone marrow transplantation. American Journal of Roentgenology. 1986;146(4):691-695.
Jones, B. ; Fishman, E. K. ; Kramer, S. S. ; Siegelman, S. S. ; Saral, R. ; Beschorner, W. E. ; Yeager, Andrew M ; Lake, A. M. ; Yolken, R. H. ; Tutschka, P. / Computed tomography of gastrointestinal inflammation after bone marrow transplantation. In: American Journal of Roentgenology. 1986 ; Vol. 146, No. 4. pp. 691-695.
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