Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles

Steven Gunawan, Joachim Petit, Christopher Hulme

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.

Original languageEnglish (US)
Pages (from-to)160-163
Number of pages4
JournalACS Combinatorial Science
Volume14
Issue number3
DOIs
StatePublished - Mar 12 2012

Fingerprint

Tetrazoles
Pyrrolidinones
Lactams
Azides
Cyanides
Amines
Acids
methyl levulinate
azidotrimethylsilane

Keywords

  • 1,5-disubstituted tetrazoles
  • Ugi reaction

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles. / Gunawan, Steven; Petit, Joachim; Hulme, Christopher.

In: ACS Combinatorial Science, Vol. 14, No. 3, 12.03.2012, p. 160-163.

Research output: Contribution to journalArticle

Gunawan, Steven ; Petit, Joachim ; Hulme, Christopher. / Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles. In: ACS Combinatorial Science. 2012 ; Vol. 14, No. 3. pp. 160-163.
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