Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles

Steven Gunawan, Joachim Petit, Christopher Hulme

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.

Original languageEnglish (US)
Pages (from-to)160-163
Number of pages4
JournalACS Combinatorial Science
Volume14
Issue number3
DOIs
StatePublished - Mar 12 2012

Keywords

  • 1,5-disubstituted tetrazoles
  • Ugi reaction

ASJC Scopus subject areas

  • Chemistry(all)

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