Concise two-step solution phase syntheses of four novel dihydroquinazoline scaffolds

Justin Dietrich, Christine Kaiser, Nathalie Meurice, Christopher Hulme

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Novel two-step solution phase protocols for the synthesis of dihydroquinazolines and fused dihydroquinazoline-benzodiazepine tetracycles are reported. The methodology employs the Ugi reaction to assemble the desired diversity and acid treatment enables ring-closing transformations. The protocols are further facilitated by the use of microwave irradiation and n-butyl isocyanide to control the rate of each ring-forming transformation.

Original languageEnglish (US)
Pages (from-to)3951-3955
Number of pages5
JournalTetrahedron Letters
Volume51
Issue number30
DOIs
StatePublished - Jul 28 2010

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Microwave irradiation
Microwaves
Benzodiazepines
Scaffolds
Acids
butyl isocyanide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Concise two-step solution phase syntheses of four novel dihydroquinazoline scaffolds. / Dietrich, Justin; Kaiser, Christine; Meurice, Nathalie; Hulme, Christopher.

In: Tetrahedron Letters, Vol. 51, No. 30, 28.07.2010, p. 3951-3955.

Research output: Contribution to journalArticle

Dietrich, Justin ; Kaiser, Christine ; Meurice, Nathalie ; Hulme, Christopher. / Concise two-step solution phase syntheses of four novel dihydroquinazoline scaffolds. In: Tetrahedron Letters. 2010 ; Vol. 51, No. 30. pp. 3951-3955.
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