Conduction pathways in microtubules, biological quantum computation, and consciousness

Stuart R Hameroff, A. Nip, M. Porter, J. Tuszynski

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Technological computation is entering the quantum realm, focusing attention on biomolecular information processing systems such as proteins, as presaged by the work of Michael Conrad. Protein conformational dynamics and pharmacological evidence suggest that protein conformational states - fundamental information units ('bits') in biological systems - are governed by quantum events, and are thus perhaps akin to quantum bits ('qubits') as utilized in quantum computation. 'Real time' dynamic activities within cells are regulated by the cell cytoskeleton, particularly microtubules (MTs) which are cylindrical lattice polymers of the protein tubulin. Recent evidence shows signaling, communication and conductivity in MTs, and theoretical models have predicted both classical and quantum information processing in MTs. In this paper we show conduction pathways for electron mobility and possible quantum tunneling and superconductivity among aromatic amino acids in tubulins. The pathways within tubulin match helical patterns in the microtubule lattice structure, which lend themselves to topological quantum effects resistant to decoherence. The Penrose-Hameroff 'Orch OR' model of consciousness is reviewed as an example of the possible utility of quantum computation in MTs.

Original languageEnglish (US)
Pages (from-to)149-168
Number of pages20
JournalBioSystems
Volume64
Issue number1-3
DOIs
StatePublished - 2002

Fingerprint

Quantum computers
Microtubules
Quantum Computation
consciousness
Consciousness
Conduction
microtubules
Pathway
Tubulin
Proteins
tubulin
protein
information processing
Protein
Automatic Data Processing
superconductivity
Aromatic Amino Acids
proteins
Electron mobility
Biological systems

Keywords

  • Biolomolecular computation
  • Consciousness
  • Microtubules
  • Protein conformation
  • Quantum computation

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology
  • Drug Discovery

Cite this

Conduction pathways in microtubules, biological quantum computation, and consciousness. / Hameroff, Stuart R; Nip, A.; Porter, M.; Tuszynski, J.

In: BioSystems, Vol. 64, No. 1-3, 2002, p. 149-168.

Research output: Contribution to journalArticle

Hameroff, Stuart R ; Nip, A. ; Porter, M. ; Tuszynski, J. / Conduction pathways in microtubules, biological quantum computation, and consciousness. In: BioSystems. 2002 ; Vol. 64, No. 1-3. pp. 149-168.
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