Confidence Bands for Low-Dose Risk Estimation with Quantal Response Data

Obaid M. Al-Saidy, Walter W. Piegorsch, R. Webster West, Daniela K. Nitcheva

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.

Original languageEnglish (US)
Pages (from-to)1056-1062
Number of pages7
JournalBiometrics
Volume59
Issue number4
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

Keywords

  • Benchmark analysis
  • Benchmark dose
  • Carcinogenic risk assessment
  • Low-dose extrapolation
  • Multistage model
  • Quantal data
  • Quantitative risk analysis
  • Simultaneous confidence bounds
  • Toxicology

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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