Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

Pavel Nagorny, Isaac Krauss, Jón T. Njardarson, Lucy Perez, Christoph Gaul, Guangli Yang, Ouathek Ouerfelli, Samuel J. Danishefsky

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the 'small molecule' co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.

Original languageEnglish (US)
Pages (from-to)3873-3875
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number30
DOIs
StatePublished - Jul 28 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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