Confocal microlaparoscope for imaging the fallopian tube

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recent evidence suggests that ovarian cancer can originate in the fallopian tube. Unlike many other cancers, poor access to the ovary and fallopian tubes has limited the ability to study the progression of this deadly disease and to diagnosis it during the early stage when it is most amenable to therapy. A rigid confocal microlaparoscope system designed to image the epithelial surface of the ovary in vivo was previously reported. A new confocal microlaparoscope with an articulating distal tip has been developed to enable in vivo access to human fallopian tubes. The new microlaparoscope is compatible with 5-mm trocars and includes a 2.2-mmdiameter articulating distal tip consisting of a bare fiber bundle and an automated dye delivery system for fluorescence confocal imaging. This small articulating device should enable the confocal microlaparoscope to image early stage ovarian cancer arising inside the fallopian tube. Ex vivo images of animal tissue and human fallopian tube using the new articulating device are presented along with in vivo imaging results using the rigid confocal microlaparoscope system.

Original languageEnglish (US)
Article number116010
JournalJournal of Biomedical Optics
Volume19
Issue number11
DOIs
StatePublished - Nov 1 2014

Fingerprint

tubes
Imaging techniques
ovaries
cancer
Animals
Coloring Agents
Dyes
Fluorescence
Tissue
Fibers
progressions
bundles
animals
therapy
delivery
dyes
fluorescence
fibers

Keywords

  • Confocal
  • Fallopian tube
  • Fiber bundle
  • Microlaparoscope
  • Ovarian cancer

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Confocal microlaparoscope for imaging the fallopian tube. / Wu, Tzu Yu; Rouse, Andrew R; Chambers, Setsuko K; Hatch, Kenneth D; Gmitro, Arthur F.

In: Journal of Biomedical Optics, Vol. 19, No. 11, 116010, 01.11.2014.

Research output: Contribution to journalArticle

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