Conformation of two somatostatin analogues in aqueous solution: Study by NMR methods and circular dichroism

Chantal WYNANTS, Dirk TOURWE, Wieslaw KAZMIERSKI, Victor J. HRUBY, Georges VAN BINST

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Cyclic‐disulfide‐containing analogues of somatostatin, [Xaa1= H or DPhe; Xaa3= Phe or Tyr; Xaa7= Cys, Me2Cys or Me2DCys; Xaa8= OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H‐NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.

Original languageEnglish (US)
Pages (from-to)371-381
Number of pages11
JournalEuropean Journal of Biochemistry
Volume185
Issue number2
DOIs
StatePublished - Nov 1989

ASJC Scopus subject areas

  • Biochemistry

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