The cyclic analogue of somatostatin (SRIF), D‐Phe‐Cys‐Tyr‐D‐Trp‐Lys‐Thr‐Cys‐Thr‐NH2 (CTC), exhibits good affinity for both opioid and SRIF receptor systems. Its conformational properties were examined in water by high‐field proton n.m.r. spectroscopy and compared with results previously obtained with structurally related analogues SMS 201–995 and Sandoz 204–090 in the same solvent. The assignments were made using 2 D‐n.m.r. methods, especially long‐range connectivities between neighbouring α protons, and between β and aromatic protons. The 3JNH‐cαH and Δδ/ΔT values are compatible with an equilibrium between two γ turns involving residues 2, 3 and 4 and residues 3, 4, and 5, respectively.
|Original language||English (US)|
|Number of pages||7|
|Journal||International journal of peptide and protein research|
|State||Published - Oct 1987|
- somatostatin analogue
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